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Acroli (Tacrolimus)

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Acroli is used to treat eczema (atopic dermatitis). It works by suppressing the activity of certain immune cells that cause inflammation (redness and swelling) of the skin. This relieves itching and improves rashes in atopic dermatitis.

Other names for this medication:
Acroli, Crolim, Cromus, Mustopic, Olmis, Pangraf, Protopic, Seegraf, Tacloran, Tacrel, Tacrim, Tacroderm, Tacrograf, Tacrokid, Tacrolimus, Tacromus, Tacrotor, Tacrovate, Tacroz, Tacstead, Talimus, Tarcel, Techlomus, Topgraf, Triplibact, Vingraf

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Also known as: Tacrolimus


Tacrolimus injection is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Tacrolimus works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ.

Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is to be given only by or under the direct supervision of a doctor.


Take Acroli exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

You may receive an injection of Acroli shortly after your transplant. The injection is given until you are ready to take the pill form of tacrolimus.

Take Acroli at the same time each day, with a full glass of water.

Swallow the capsule whole and do not crush, chew, break, or open it.

Mix Acroli oral granules with water right before you take them. Do not save this mixture for later use. Do not get the powder or mixture on your skin or in your eyes. If this happens, wash your skin with soap and water or rinse your eyes with water.

You may take Acroli with or without food, but take it the same way each time.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. All forms of tacrolimus are not equivalent and may not have the same dose or schedule. Avoid medication errors by using only the form and strength your doctor prescribes.

You will need frequent medical tests, and your blood pressure will need to be checked often.

Store at room temperature away from moisture and heat.

Detailed Acroli dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acroli are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Acroli if you are allergic to tacrolimus or hydrogenated castor oil, or if you have used cyclosporine (Neoral, Sandimmune, Gengraf) within the past 24 hours.

Using Acroli may increase your risk of developing serious infections or certain types of cancer, such as lymphoma or skin cancer. Your risk may be higher if you are treated over long periods of time with drugs that weaken the immune system. Ask your doctor about this risk and about symptoms to watch for.

Some people taking Acroli after a kidney transplant have developed diabetes. This effect has been seen most commonly in people who are Hispanic or African-American.

To make sure Acroli is safe for you, tell your doctor if you have::

problems with your liver, kidney, or heart that are not related to your transplant; long QT syndrome (in you or a family member); or if you are scheduled to receive a vaccine;

Tell your doctor if you plan to get pregnant. Tacrolimus may harm an unborn baby, and can worsen conditions such as diabetes or high blood pressure in the mother. Use effective birth control before and during treatment with Acroli.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of tacrolimus on the baby.

If you are a man, use birth control before and during treatment with Acroli if your sex partner is able to get pregnant.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

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