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Adalat (Nifedipine)
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Adalat

Adalat is a calcium-channel blocker. It affects the amount of calcium found in your heart and muscle cells. This relaxes your blood vessels, which can reduce the amount of work the heart has to do. This medicine is used to treat chest pain caused by angina.

Other names for this medication:
Addos, Antrolin, Aprical, Atenerate, Belnif, Bresben, Calchan, Calcibloc, Cardalin, Casanmil, Citilat, Cobalat, Cordalat, Cordipin, Corinfar, Corotrend, Depicor, Depin, Depine, Duranifin, Epilat, Ficard, Ficor, Macorel, Milfadin, Nefelid, Nicardia, Nidicard, Nifatenol, Nifcal, Nifecap, Nifediac, Nifedicor, Nifedigel, Nifedin, Nifedipin, Nifedipress, Nifestad, Niften, Nipidin, Pressolat, Tenif

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Also known as: Nifedipine

Description

Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adalat PA 20. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Adalat and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Adalat are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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Cholinergic, monoaminergic and peptidergic innervation of the primary visual centers in the brain of the lizards Gekko gecko and Gallotia galloti. Although this study reflects only the histologically diagnosed tumors, it is headway towards diagnosing the incidence of all CNS tumors in Puerto Rico. Jejunoileal bypass for obesity has been shown to be associated with increased hepatic triglycerides during the period of brisk weight loss. Discrete patches of spongiform degeneration have been found in the cerebral cortex of three rats, 28 and 30 months of age. Occult axillary lymph node metastases from breast cancers with intramammary lymphatic tumor emboli. The glutathione and cysteine conjugates of microcystin (MC-GSH and MC-Cys, respectively) are two important metabolites in the detoxification of microcystins (MCs). For node-negative patients we assessed the influence of patient, hospital, and tumor factors on lymph node counts and survival. Moreover, adsorbed molecules occupy the external surface of the slit pores (the entrances) in the case of oxidized adsorbents. Risk factors include preoperative voiding accommodations such as straining or bending over to void, but other variables including urodynamics did not predict incomplete bladder emptying after MUS. intermedius) skeletal muscle was estimated 5 days after 3 h, 6 h or 9 h prolonged running at a speed of 13.5 m/min.

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Biochemical studies demonstrated that yeast does indeed possess a bona fide histone H1. Wine is one of the most consumed beverages over the world containing large quantities of polyphenolic compounds. There is also evidence that certain non-neoplastic disorders, such as pneumoconiosis and excess fetal deaths, may be associated with this chemical. In combination with G-CSF-induced leukocytosis, increased peripheral neutrophils could aggregate within microvasculature and additionally impair blood perfusion of the ischemic tissue. Loci of signal probability effects and of the attentional blink bottleneck. Helicobacter pylori infection in the antral mucosa may induce duodenal ulcers by its effect on acid secretion, as in patients with gastrinoma. Implications for job insecurity measurement and theory are discussed. An estimate of the 60Co gamma attenuation in the small phantom enployed in the definition of tissue air ratio. The homogeneous-gamma-G-immunoglobulin produced by mouse plasmacytoma 5563 and its subsequent heterogeneity in serum.

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Evaluating the cutaneous involvement in scleroderma: torsional stiffness revisited. STD epidemics in developing countries may not follow the dynamic topology that is common in developed countries. Distinct Translaminar Glutamatergic Circuits to GABAergic Interneurons in the Neonatal Auditory Cortex. Lack of association among five genetic polymorphisms of the renin-angiotensin system and cardiac hypertrophy in patients with aortic stenosis. Whether this effect generalizes to the natural environment, however, remains unknown, and studies have not examined whether craving predicts drinking among youths. The sensitivity of a spectral SPR biosensor with a fused silica prism was 1.6 times higher than that with a BK-7 prism at the same incidence angle of 46.2 degrees. An extensive basal lamina was present when the neuronal cell population was added to the developing myotubes in culture. Very little information is available on the structure and characteristics of the mouse Mx1 protein itself.

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Here we show that PAR1 increases the invasive properties of tumor cells primarily by increased adhesion to extracellular matrix components. Angiotensin converting enzyme inhibition and dihydropyridine calcium channel blockade in the treatment of left ventricular hypertrophy in arterial hypertension. Subsequent reports of reactions to natural disasters supported the notion that intense negative emotions could precipitate somatic disorders such as CHD. Ameloblastoma of the jaws: a critical reappraisal based on a 40-years single institution experience. The results showed relatively high capacities of carbons for removal of CH3SH. coli strains isolated from the urine of 194, 76 and 107 subjects suffering from cystitis, pyelonephritis and prostatitis, respectively, and 50 isolates from the feces of healthy individuals were examined for genotypes and serotypes. Synergic bactericidal effects of reduced graphene oxide and silver nanoparticles against Gram-positive and Gram-negative bacteria. Reductions in inflammation and fibrosis were among the most prominent changes observed.

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They are inserted for various reasons including social pleasure. A greater understanding of the motivations of carers may aid the recruitment and retention of participants in clinical trials. Extent of fussing and colic type crying preceding atopic disease. Results were assessed using two outcome measures-the percentage reduction in hair density and the hair-free interval. On admission, each patient completed a visual silhouettes scale of actual self and ideal self, as well as the Attitudes Toward Obese Persons (ATOP) scale. More effective drugs are needed for the treatment of human filarial diseases and the elimination of these infections as a public health problem. Neutrophil-depleted animals consistently demonstrated more severe brain abscesses and higher CNS bacterial burdens compared with control animals.

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A pilot evaluation of the diagnostic value of body mass index in elderly men with metabolic syndrome. Though PhLP has been shown to bind Gbetagamma in vitro, little is known about its physiological function. These products are principally designed for use in the developing world and must therefore address cultural and societal issues generally unknown in the developed world. To analyze and compare the characteristics of dose distributions for Leksell Gamma Knife Perfexion (LGK-PFX) and CyberKnife (CK) in treating arteriovenous malformations (AVMs). These findings indicate that the AT2R gene may not play a major role in the development of renal hypoplasia and other CAKUT in humans, at least in the Japanese population. The application of the ALCP indicators at the province level led to the identification of inequalities in the development and distribution of services across the country.

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Public opinions on tax and retail-based tobacco control strategies. aeruginosa PAO1 was markedly sensitive to UV-B irradiation exhibiting a decrease in survival of 6 orders of magnitude following a UV-B dose of 250 J m(-2). Although multimodal therapy concepts tend to improve survival rates, postoperative morbidity and mortality rates are increased. A novel magnetic/photoluminescence bifunctional nanohybrid for the determination of trypsin. Type III collagen in the annulus fibrosus of the degenerated intervertebral disk. Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation. The objective was to study the epidemiology, risk factors, behavioral and learning problems associated with enuresis in children 5-15 years old. In all organs studied, cholinergic innervation was more developed than noradrenergic innervation. Additional subdivision of the frequency bands for independent encoding, so as to increase the noise at TOD and thereby reduce the required SNR, is particularly effective at the lower speech frequencies, because it allows one to take advantage of both the rapidly dropping speech spectrum as well as the time incoherence of the speech energy variations within the various bands.

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Accurate determination of the location and extent of a spinal cord leson is essential to the ongoing therapeutic plans for a patient as well as for overall program evaluation in a spinal cord center. Immunoglobulins transferred in quantity in utero or via the colostrum are mainly of the IgG class. The urogenital system of PAX2 null male mice fails to develop properly. Particle-size and velocity measurements in flowing conditions using dynamic light scattering. NQO1 activity was determined in cytosol from normal, APAP and PBC liver specimens. The sample for the study consisted of 75 school children aged 8-12 years with four or more (decay component) of decayed, missing, and filled teeth index.

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The term simple schizophrenia was firstly used in the early twentieth century to designate a formal variety of schizophrenia. a new marker proposed as a diagnostic tool for bacterial infections, triggers a systemic-inflammatory reaction in the body (sepsis, septic shock) and has potential use in a wide range of patient settings. The large second-order optical susceptibility, which can reach 3.7x10(-7) esu, exhibits a strong magnetic-ordering dependence, giving rise to magnetic-field controllable SHG response in polar magnets. Even though the fibromyalgia riddle is not yet fully solved, research over the last decade has given valuable new information on pathogenesis and treatment. The in-vitro-study was followed by a prospective clinical study with 21 patients. The prognosis of patients was related to clinical stages, treatment and cryptorchidism. The Smith-Purcell FEL is therefore a backward wave oscillator in which, if the beam current exceeds a certain threshold known as start current, the optical intensity grows to saturation even if no mirrors are employed for feedback.

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Blood and lymphatic vessels are not evenly distributed in normal limbal areas. The results of the study suggest that in patients 50 years of age and older, early surgical decompression combined with intravenous antimicrobial therapy was not associated with superior clinical outcomes when compared with intravenous antimicrobial therapy alone. Biofilms, predominantly planktonic, were present on 8 of 9 adenoids excised because of hypertrophy. An indium(III)-water chain based on an unusual acyclic water pentamer. Maternal plasma sodium and total osmolality were reduced during the last week of pregnancy despite the salt retention, suggesting an increased fetal usage. Then, they received training with vibrotactile, auditory, and fall-warning visual feedback during stance tasks before being reassessed with feedback.

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Combination approaches hold considerable promise, including combined use of statins with fibrates, niacin, and the new sterol absorption inhibitors. Establishment of eco-sensitive zones (ESZs), which act as buffer areas around the core forests, is one of the key approaches towards achieving this goal. Our main application is an integrated faceted search in nephrology based on information extraction results. C3 excluder results are comparable to those of the previous device in spite of more comorbidities and complex anatomy of the treated patients. Prevention of relapsing mediocrity: how to maintain performance improvement in hospitals. Low physical activity as a key differentiating factor in the potential high-risk profile for depressive symptoms in older adults. The relative magnitudes of the quantum and the anatomical variability are investigated as an approximation to the effects of exposure time. He was diagnosed and treated for epilepsy and insufficient adrenal function for four years with no response. Classical screening methods are incapable to properly detect LTBI (Latent TB Infection) and HCWs (Healthcare Workers) are at the high risk of exposure. Prediction data are given for the various morphometric variables studied.

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Gemcitabine as single agent in the treatment of elderly patients with advanced non small cell lung cancer. An association has been reported between mutations in the FSH receptor (FSHR) in a family with increased twinning frequency. The general caspase inhibitor z-DEVD-FMK and the specific inhibitor of caspases-3 DEVD-CHO exerted the protective effect against the ciglitazone-induced cell death. ATP synthase is also thought to have a role in crista morphogenesis. It is shown that the measured change of the amount of water in contact with protein during the course of the reaction modulated by an osmolyte is a change in preferential hydration that is strictly a measure of the cosolvent chemical potential perturbation by the protein in the ternary water-protein-cosolvent system. Both of the monkeys infected with the chimera elicited a humoral antibody response against the virus. The development of Near Infrared desyrel mg Spectroscopy has paralleled that of the PC, and the application of NIR in many industries has undergone explosive growth in recent years.

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Two new compounds from the fungus Penicilliumcrustosum YN-HT-15. Even at the lowest dose level tested (paclitaxel 135 mg/m(2) followed by ifosfamide 1 g/m(2)/day x 4 days) grade 4 neutropenia was almost universal, despite the routine use of G-CSF. We have identified new SMC homologs, created a new SMC phylogeny and identified shared DNA and protein motifs. The findings show the specific effect of hydrochlorothiazide treatment to be a decrease in urinary calcium excretion in patients with calcium lithiasis, while other changes appear to be nonspecific effects of treatment. Neither NMMA nor hemoglobin altered the basal release of PGE2, which indicates that NO is not responsible for basal PGE2 release. The authors describe two patients who died during hyperthermic reaction following the administration of MAO inhibitors and tricyclic antidepressants in therapeutic doses. A transmastoidal approach was used to amputate the meningoencephalocele and modified (Mini-Craniotomy) in the second (male) patient. The result is an increased clearance of LDL particles from the bloodstream and by this mechanism statins have proved to be highly effective in reducing the cardiovascular risk, as amply documented in clinical studies confirming inhibition of atherosclerosis.

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Th17: a new participant in gut dysfunction in mice infected with Trichinella spiralis. Functional changes in brain regions activated by noxious or non-noxious stimuli of the sciatic nerve were investigated using fMRI in a 4.7 T MR system in alpha-chloralose anaesthetized rats. The net polar atomic charges can be computed simply, so they can be used in high throughput screening of oral drugs. Cytokine production in whole blood cell cultures of patients with B-lineage acute lymphoblastic leukemia. When Ar is a low-aromaticity homo- or heterosystem, the sulfonyl-stabilized anion of nitrobutadienes 4 (which derive from the initial ring opening of 3-nitrothiophene) undergoes a rather surprising addition onto the aromatic ring itself, thereby leading to the construction of an unusual eight-membered sulfur heterocycle condensed with the original Ar ring. The effect of repetitive flexion and extension fatigue loading on the young porcine lumbar spine, a feasibility study of MRI and histological analyses. The Brk DNA binding activity was localized 50 mg tramadol images to an amino-terminal region containing a putative homeodomain.

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