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Adefin (Nifedipine)

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Adefin is used to treat high blood pressure or angina (chest pain). For high blood pressure: Adefin works by relaxing and expanding the blood vessels. This makes the blood flow more easily and lowers blood pressure. Lower blood pressure reduces the strain on your heart. For angina: Adefin works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.

Other names for this medication:
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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adefin PA 10. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adefin and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Adefin dosage information

Side effects

The most common side effects associated with Adefin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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The results of a score created to evaluate the inhalation technique were compared with age, MMSE, Barthel Index, FEV(1), maximum inspiratory and expiratory pressures, and peak inspiratory flow (PIF). Two modern foldable IOLs, the silicone plate-haptic large-hole and the silicone polyimide-haptic, appear to be more prone to damage during folding, loading, and implantation than other IOLs. Training and assessing complex decision-making in a virtual environment. Usefulness of a VDD defibrillation electrode in recording atrial electrograms during atrial flutter and atrial fibrillation. Transcriptomic Profiling of the Allorecognition Response to Grafting in the Demosponge Amphimedon queenslandica. Membranes treated with sodium carbonate, pH 11, or with protease K, were still pelleted by zymogens, suggesting that the aggregated zymogens bound to membrane lipids. She visited the department of urology in our hospital in August, 1999 complaining of gross hematuria.

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High-precision measurement of the analyzing power in large-Pperp2 spin-polarized 24-GeV/c proton-proton elastic scattering. The underlying mechanisms whereby PPIs may affect gastric emptying have been discussed, most of which still remain hypothetic. Cholesterol and glycerol alcohols were measured in the serum using Cholesterol and Triglycerides kits (Hoffmann la Roche). Western analysis and exoribonuclease activity assays showed a threefold increase in RNase II in the gmr deletion strain. Controls consisted of intact 14-day embryonic rat bladders with the urothelium not removed, and 14-day embryonic bladder mesenchyma recombined with urothelium (direct contact) placed within the sub-detrusor space of the bladder and under the renal capsule.

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Cell production in the medial and lateral ganglionic eminences in pre- and post-natal mouse brains was studied by recording the number, location and plane of cleavage of mitotic figures. Spatio-temporal image correlation associated with the tomographic ultrasound imaging mode (TUI-STIC) is a new modality that allows a complete sequential analysis of cardiac structures to be displayed on a single panel by showing all echocardiographic transverse views at the same time. Behavioral results indicated a strong preference for using the allocentric reference frame and a preference for choosing the rewarded place in the next trial, suggesting that participants developed probabilistic expectations between places and rewards. A one-day training course can significantly enhance GP detection rates of psychological distress and suicidal ideation in young patients, but higher recognition rates do not necessarily lead to changes in patient management. In pancreatic islet transplantation, early revascularization is necessary for long-term graft function. Beyond epidemiological differences, it has been controversial whether any important sex differences exist in the treatment of stroke.

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New characteristics of anti-factor VIII inhibitor antibody epitopes and unusual immune responses to Factor VIII. In training, swimming times were faster and blood lactate concentrations were higher (10.2 vs. As volunteers, 95 used the diet in preparation for deployment and 39 used it in preparation for return. Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2. A small molecule chemical chaperone optimizes its unfolded state contraction and denaturant like properties. The content variation of the midgut, malpighian tubules and fat bodies in the larvae was observed microscopically, and the genomic DNA of the larvae was extracted for electrophoresis to identify the target bands. The tumor cells stained positively for the CD3 antigen and negatively for a B-cell marker. Failure of resolution and negative screening tests for sexually transmitted diseases prompted a skin biopsy and extensive literature search, with an ultimate diagnosis of nonvenereal sclerosing lymphangitis of the penis, a rare, self-limiting condition.

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Avoiding major (above-ankle) amputation in patients with diabetic foot ulcers is best accomplished by multidisciplinary care teams with access to infectious disease specialists. Although mechanisms regulating replication timing are not clear, novel genome-wide studies provide a thorough survey of the extent to which replication timing is regulated during most of the early cell fate transitions in mammals, revealing coordinated changes of a defined set of 400-800 kb chromosomal segments that involve at least half the genome. CIE induced significant changes in protein levels in dependent mice compared with their non-dependent controls. In addition, this study determined risk factors that are associated with local recurrence of enchondroma or ACT treated with curettage. A 48-year old male with longstanding and extensive pancolitis developed a high grade and rapidly lethal malignant lesion in the ascending colon characterized by a neuroendocrine carcinoma. Ambulatory sleep recording for 8 h was performed using Embletta PDS (Medcare, Iceland) in 74 patients with CHF, and the left ventricular ejection fraction (LVEF), internal end-diastolic diameter (LVIDd) and left ventricular mass weight (LVMW) were measured using M-mode and two-dimensional echocardiography. There is a scientific and clinical need for FIGO to adopt the recommendations of the majority of physicians with expertise in treating trophoblastic disease for a rational classification of trophoblastic disease. A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function. In the state after transplantation, hyper-intense lesions on FLAIR and DWI represented in the brain from the initial stage, we might be care of other severe complications but for neurotoxicity. The introduction of clonal assays and long-term culture systems has resulted in considerable progress in the understanding of the early events that control self-renewal and commitment to differentiation of pluripotent hematopoietic stem cells (PHSC).

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The detailed structural and kinetic data sets of the human liver microsomal CYP3A4-mediated reactions represent a specialized database useful for researchers working in the area of structure-metabolism relationship modeling and analysis. The ability to understand and to control the protein concentration profile in the frozen state offers the potential to improve stability of protein in long-term frozen storage. The low use of GI protection is carried on in primary care after discharge. Our findings imply the concept of elastic deformation is relevant on lengths approaching the bilayer thickness and less (the mesoscopic scale), and suggest that application of combined R(1Z) and S(CD) studies of phospholipids can be used as a simple membrane elastometer. We evaluated therapies receiving at least a Grade 1B from the American College of Gastroenterology Task Force for IBS or which passed recent phase III clinical trials.

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To review the pathophysiology and characteristic pathologic patterns of this disease and discuss the possible mechanisms of production of the lesions. Femtosecond relaxation of localized plasma excitations in Ag islands. The patient was given a course of radiotherapy, but clinical and radiological examination 8 months later revealed lung metastases and chemotherapy was started. A report of Committee 3 of the International Commission on Radiological Protection. Intracranial tuberculoma: case report and review of the literature.

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This fact is particularly crucial for in vivo applications in the brain, where delivery of macromolecules is limited by the blood-brain barrier. A lower costly laparoscopic appendectomy: our experience of more than 2000 cases. Inclusion criteria were controlled clinical studies on parameters associated with survival in cancer patients treated with Iscador. It is suggested that in the CNS there exist at least two types of dopamine receptors one of which is involved in the hypersensitivity mechanism after long-term administration of neuroleptics (post-synaptic receptors), while another one in the hypersensitivity to the effects of long-term administration of dopaminomimetics (presynaptic receptors). These findings suggested that specific adenosine receptors contribute to airway responsiveness and airway inflammation associated with this model of allergic asthma. Special attention must be paid to patient positioning following the operation. Comparative genomic study of ALDH gene superfamily in Gossypium: A focus on Gossypium hirsutum under salt stress. However, more multicenter, randomized, controlled trials are urgently needed to verify these differences. HPLC fingerprints combined with principal component analysis, hierarchical cluster analysis and linear discriminant analysis for the classification and differentiation of Peganum sp.

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Total, mean, and duration of vasopressor dosing requirements were obtained for study participants. In patients with intrathecal baclofen infusion therapy (IBT) pump implantation, infection via the skin and soft tissue may be an issue of concern. The flowering and the release of the pollen of the plants allergens are significant phenologic phases for human health. The mechanisms underlying attention to action are poorly understood. PS/gammaS processing of CD46 releases immunoprecipitable cyt1 and cyt2 tail peptides into the cell, is blocked by chemical inhibitors, and is prevented in dominant negative presenilin mutant cell lines. Do we need to consider non-linear information flow in corticomuscular interaction?. Morphine versus haloperidol catalepsy in the rat: a behavioral analysis of postural support mechanisms.

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The Nampt-induced expression of TRPC1 was attenuated by pre-treatment with pravastatin, whereas promoted by pre-treatment with thapsigargin. To evaluate the expression of multiple lymph-specific markers and to test its association with histopathological characteristics and clinical outcomes in patients with urothelial carcinoma of the bladder (UCB) treated by radical cystectomy (RC). Characterization of a new picornavirus isolated from the freshwater fish Lepomis macrochirus. Thiol oxidation to disulfides and the reverse reaction, i.e., disulfide reduction to free thiols, are under the control of catalysts in vivo. EDTA and EDDS, on the metal phytoextraction capacity of Brachiaria decumbens was studied. To help prevent congestion, our system dynamically reassigns characters in the formation by employing a mass transport solver to minimize their overall movement. Infracardiac type total anomalous pulmonary venous return with obstruction and dilatation of portal vein. Spatial and Temporal Patterns of Neurogenesis in the Chick Retina. On spatially selective RF excitation and its analogy with spiral MR image acquisition. Electronic structure and photoexcited-carrier dynamics in nanometer-size CdSe clusters.

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The story of the rise and fall of interest in the anticancer properties of T. Radiotherapy following the meaning of GOA (Fee Regulations for Physicians) and E-Adgo. beta-AR stimulation increases levels of Ub in the conditioned media. Double labeling has shown that the RhIc-labeled cells were immunoreactive with ED-1, OX-42, OX-18, and OX-6, confirming their microglial nature. Collectively, our data suggest that RNF125 plays a new role in innate immune response by regulating TRIM14 ubiquitination and degradation. We describe the case and associated neuroimaging of an E200K-129M gene-mutation-related fatal spongiform encephalopathy with resultant clinical insomnia and thalamic changes. Protein content was attenuated only by treatment with 200 ng/ml of DON throughout the experimental period.

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Nonetheless, BDNF levels increase after antidepressant treatment, along with symptom recovery, to those seen in healthy control subjects. We decided to assess the current frequency of MGD in seemingly sporadic primary hyperparathyroidism. Post resuscitation myocardial stunning is well described and recognized as a significant contributor to poor long-term outcome following cardiac arrest. As its expression seems to predict unfavorable prognosis, at least in some cancers, it also may become a potent prognostic marker. The degradation of long-chain n-alkylbenzenes and n-alkylcyclohexanes by Alcanivorax sp. Transfusion support with RBCs from an Mk homozygote in a case of autoimmune hemolytic anemia following diphtheria-pertussis-tetanus vaccination. Unlike normal linker histones, H1.X is a cytoplasmic as well as a nuclear protein and is not associated with chromosomes. Nail-gun accidents have become a common reason for penetrating ocular injuries in patients presenting to the emergency room with globe trauma. This review will also update readers about the progress made in the field of Plk1 inhibitors.

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The precise control of the Co/Mo molar ratio in the Co-PCG precursor is of critical importance to synthesize pure phase bimetallic carbide of Co6Mo6C2. Appropriate psychometric instruments were applied in the study population followed by (1)H- MRS. The technique used eliminates any problems resulting from detergent binding to the protein, is independent of the particular detergent used (in this case the nonionic n-octyl beta-D-glucopyranoside), and gives the apparent weight-average molecular mass at different protein concentrations, allowing extrapolation to zero concentration. We evaluated fluorodeoxyglucose biodistribution visually and quantitatively in HIV-negative individuals and various groups of HIV-infected patients to determine the impact on the pattern of nodal activation of HIV infection, the stage of HIV infection and degree of viremia, and HAART. A 19-year-old male presented with sudden onset of right hemiparesis caused by left cerebral hemorrhage. Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity. There is no official form for submitting a United States premarket notification or 510(k) submission. Food restriction at 26 weeks of age reduced proteinuria, while restriction at 50 weeks prevented further increases in proteinuria without altering pre-existing hypercholesterolemia, hypertension, or hyperinsulinemia. Low-fat meat sausages with fish oil: optimization of milk proteins and carrageenan contents using response surface methodology.

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The cultures were also transfected with plasmids, causing over-expression of Smads or Runx2, or both. Based on these results we propose the following minimal scenario for T. Treatment results with this regimen were similar to those reported for other combined frontline chemotherapy regimens for colorectal cancer. The aims of the present study were to assess caries experience among Brazilian children aged eight to 10 years and determine social factors of this disease, through a multilevel approach. The dose-response curve was linear between 40 and 120 mg/kg ketamine with constant 10 mg/kg xylazine. Platelet-activating factor-acetylhydrolase can monodeacylate and inactivate lipoteichoic acid. Functional imaging of sympathetic activation during mental stress. More efforts should be made by the healthcare community to promote prostate cancer screening education and physician-patient discussions.

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prospective cohort study of 258 consecutive patients undergoing infra-inguinal bypass grafts in one centre between 1995-99. Twodimensional cultures might nevertheless present valuable complements to other models for the study of the activities of invasive cells. This critical review focuses on the synthesis and physical properties of these fascinating materials. APBI in Japanese women provides satisfactory clinical results except for cosmetic outcomes. The displacement of the brain stem by the hematoma is frequently associated with a seventh nerve palsy on the side of the hemorrhage. An open study of B-lymphocyte depletion was undertaken in rheumatoid arthritis (RA) patients to test the hypothesis that B lymphocytes may be essential to disease is there a generic version of zyrtec perpetuation. In recent years, there has been much interest in the role plant-derived polyphenols play in the regulation of oxidative stress and autophagy. 2013 European Guideline on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens.

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Sex-specific biotransformation and detoxification after xenobiotic exposure of primary cultured hepatocytes of European flounder (Platichthys flesus L.). The Brazilian Society of Senology established the current norms for its practice. Interestingly, obesity-related traits were associated with distinct aspects of LV mechanics, underscoring potential differential effects along specific LV planes of deformation. Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. Stable transformation using Agrobacterium tumefaciens generates stable lines for downstream experiments, but is time-consuming. Changes in von Willebrand factor and factor VIII levels during the menstrual cycle. Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes.

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Low-income children in this region may benefit from regular access to fluoride varnishing treatments and/or use of fluoridated mouthwash, interventions that could be tested in future well-designed trials. Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery. Changes in the spleen and liver increased with increases in dose and with increased time following intranasal inoculation with B melitensis 16M. A short, unsupported CuI...CuI interaction, 2.65 A paxil medication guide , in a dinuclear guanidine chloride complex. 2 modifications of the calcium-cobalt method for cytochemical determination of alkaline phosphatase in leukocytes of the blood and bone marrow. Trials that included women with post menopausal bleeding, intermenstrual bleeding and pathological causes of heavy menstrual bleeding were excluded. In women, NO3- significantly correlated with age, systolic blood pressure, and total cholesterol with a simple correlation. While the final versions of these phantoms are in a voxelized format for radiation transport simulation, their primary format is given as NURBS and polygon mesh surfaces, thus permitting one to sculpt non-reference phantoms using the reference phantoms as an anatomic template.

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According to electron microscopy data, the most pronounced effects of cycloheximide in the presence of cyanide were autophagy and a lack of apoptotic condensation of nuclear chromatin, the prevention of chloroplast envelope rupturing and its invagination inside the stroma, and the appearance of particular compartments with granular inclusions in mitochondria. There are few successful attempts to identify genes for common, non-Mendelian diseases such as diabetes, hyperlipidemia, hypertension, etc. A new senior ED was not associated with reduced ED recidivism or hospital length of stay, but was associated with decreased rate of admission. This includes a consideration of both the internal and external ways in which eating environments are now constructed. After palliative lower anterior resection, histologic examination of the resected specimen revealed basaloid differentiation with keratin pearls, and tumor cells were positively stained with high molecular weighted cytokeratin (34BE12) and CK 5/6. Accumulating evidence suggests that cancer/testis antigens may serve as indicators of tumor malignant phenotype. The activation of protein kinase C (PKC) with 12-O-tetradecaoylphorbol-13-acetate (TPA) also induced increases in junD expression similar to those of UV irradiation. Using SEM-EDS, the metal in the heel of a glass bottle was identified as copper sulfide-containing metal inclusion. Dermoscopic rosettes as a clue for pigmented incipient melanoma. The aim is to elaborate the recommendations for the standardization of the treatment of critical patients.

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The formulation presented in this paper provides a technique for solving half-space problems under local plane-wave illumination. Gene duplication, lineage-specific expansion, and subfunctionalization in the MADF-BESS family patterns the Drosophila wing hinge. To report the prevalence of three non-carious tooth conditions in children in the UK theophylline solution brand name . After deposition in the cell matrix, non-reducible cross-links between the 7S domains are formed while the globules of two procollagen molecules connect to each other. 1,1,1-Trifluoro-2,5-hexanedione does not form pyrroles, but the three 2,5-HD analogues with an electron-withdrawing 3-substituent all rapidly formed pyrroles that were inert to autoxidation. Thus, this study not only emphasizes the importance of assessing heavy metal toxicities at multiple levels but also provides a new perspective on how Fe deficiency contributes to the toxic action of individual heavy metals. The primary aim of this study was to examine BFSE in a sample of women using second-line strategies for feeding healthy term infants in the first week postpartum. The authors come to a conclusion on high incidence and multifactorial toxic effects of ephedrone and multilevel somatic involvement in ephedrone narcomania. Our new synthetic strategy for assembling polyacetate structures features efficient cross-couplings of six-carbon modules derived from any stereoisomer of the epoxyalkynol derivative (1).

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Irrespective of the resectional approach, routine use of intraoperative ultrasound, maintenance of a low central venous pressure during parenchyma transsection, intermittent hilar clamping, and ischemic preconditioning all contribute to a safe and oncologically effective operation. During neural differentiation, dramatic enrichment of H3K27me3 and H3K9me3 (repressive marks) was observed on Oct4 and Nanog regulatory regions. However, the average cost per detected case of amblyopia among high-risk children is lower than the cost of screening all children in this age range. The possibility of local recording of the electrical activity of the sinus node was investigated on 22 dogs. The first survey of airborne trace elements at airport using moss bag technique. Further analysis is necessary to assess the usefulness of zyrtec pediatric dose PCA3 in combination with other biomarkers or in selected subsets of patients undergoing surveillance. Intraprostatic spermatozoa: zonal distribution and association with atrophy.

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