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Adiff (Adapalene)

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Adiff is an expensive drug used to treat mild to moderate acne. This drug is slightly more popular than comparable drugs. It is available in generic and brand versions. Over-the-counter Adiff is now available without a prescription.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Colcrys, Adalat, Sinequan, Motrin, Flonase, Nexium, Capscare, Grenis, Prosed, Renacor, Etotan, Nidagen, Metsig,

Also known as: Adapalene


Adiff (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Adiff is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


Usual Adult Dose for Acne:

Adiff 0.1% cream, 0.1% gel, 0.3% gel: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.

Usual Pediatric Dose for Acne:

Adiff 0.1% cream, 0.1% gel, 0.3% gel: 11 years or less: Safety and efficacy have not been established. 12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.

Detailed Adiff dosage information


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Adiff dosage information

Side effects

The most common side effects associated with Adiff are:

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There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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We examined ryk expression in adult mouse epithelial tissues and during embryonic development at the histological level. To determine the toxicity and efficacy of concurrent 5-fluorouracil (5-FU), cisplatin, and paclitaxel (Taxol) and hyperfractionated radiotherapy in locally advanced squamous cell carcinoma of the head and neck. A motor brain mapping was performed in three right handed patients without any neurological deficit, operated on for a slow growing lesion near the rolandic region (two precentral resected under general anaesthesia and one retrocentral removed under local anaesthesia to allow also sensory mapping) using intraoperative direct electrical stimulations (5 mm space tips bipolar stimulator probe, biphasic square wave pulse current: 1 ms/phase, 60 Hz, 4 to 18 mA). We present the case of an older female patient diagnosed with bullous pemphigoid, who presented with an unusual combination of blisters and figurate erythema outside the area of blister formation. Stress-induced DNA duplex destabilization in transcriptional initiation. Beta2-adrenoceptor polymorphism and bronchoprotective sensitivity with regular short- and long-acting beta2-agonist therapy. Variation of blood-pressure in untreated hypertensive outpatients. The pattern of human migration is therefore an important underlying determinant of Chagas disease risk in and around Arequipa. The gastric mucosa of C48/80-treated rats had decreased Se-glutathione peroxidase activity and vitamin E, ascorbic acid, and hexosamine contents and increased myeloperoxidase and xanthine oxidase activities and thiobarbituric acid reactive substances content at 3 h after the treatment. Also, application of the agents caused a decrease in amplitude and an increase in rate of respiratory thoracic movements.

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A model for inferring the voluntary and involuntary causes of residential segregation. Using fission yeast, we report that Rad52 and the DNA binding activity of Rad51, but not its strand-exchange activity, act to protect terminally arrested forks from unrestrained Exo1-nucleolytic activity. By examining data on actual conversions to cash balance pension plans, the author challenges the validity of major criticisms faced by employers sponsoring cash balance plans and their advisors. Our results show that LB are made of lipids, neutral mucosubstances, and nonsulfated acid mucosubstances, and that hormonal (steroids) and dietary factors (lipids) influence their accumulation. These should focus on patients from one age group to give clinicians the details required to identify those at highest risk.We present a case-control study of 63 patients who committed suicide and 63 controls from a consecutive admission series of patients with a diagnosis of schizophrenia.

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On the regulation of the carbohydrate catabolism in the ischemic heart muscle of the theolair dog. Surfactant protein B gene polymorphism is associated with severe influenza. Patients and family members in a radiation oncology department participated in a study of a new education/orientation program. Hydroxyethylflurazepam and desalkylflurazepam are the metabolites suitable for proving a previous flurazepam ingestion. Cancer vaccines have repeatedly been shown to be safe with production of minimal toxicity. Investigations of mechanisms responsible for the development and maintenance of atrial fibrillation have highlighted the importance of gap junctional remodeling. Two lines of a spirochete were isolated as contaminants in a culture of a leptospire and from a bottle of uninoculated medium. The potential energy of the system is thus lost as heat, and, in plants with high levels of the alternative oxidase, this results in thermogenesis. Results correlated with the degree of phoneme opposition and with phonological loop capacity.

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Role of neurotransmitter autoantibodies in the pathogenesis of chagasic peripheral dysautonomia. Overlapping MALDI-Mass Spectrometry Imaging for In-Parallel MS and MS/MS Data Acquisition without Sacrificing Spatial Resolution. After recalling the latest finding on the pathological anatomy, physiopathology, symptomatology, diagnosis and surgical therapy of hepatic echinococcus with intrahepatic bile duct fistulas, the personal series and that of the Palermo Surgical Pathology School is illustrated. The high-boiling n-alkanes in the wax were associated with microbial degradation of the oil and appeared to be similar to components of tarballs found in the open ocean. Norepinephrine caused a significant increase in heart work, energy utilization, and mechanical efficiency of the normal and failing heart. The unusual domain arrangement may be crucial for the modulation of interactions with other co-regulatory molecules such as cyclin-CDK complexes, and has implications for the quaternary interactions within the multisubunit SBF and MBF transcription complexes.

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Ontogeny of excitation-contraction coupling in the mammalian heart. Dose assessment was performed for clinically relevant paediatric angiographic or chest detrol 5 mg /mediastinum acquisition protocols with tube voltages of 80 or 100 kVp and tube currents between 40 and 80 mA. Depolymerizable Poly(O-vinyl carbamate-alt-sulfones) as Customizable Macromolecular Scaffolds for Mucosal Drug Delivery. Subsequently, the operator selects combinations of measurements for interactive analysis. Current therapeutic approaches to control chronic hepatitis such as interferon-alpha and lamivudine are unsatisfactory. In cultures under experiment the first enzyme was found to be lost at 5, 8, 18 days of infection and its activity to be enhanced on the 24th day. Specifically targeting mast cell migration into the ASM bundle may provide a novel treatment for asthma.

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The pulmonary vascular effects of three prostaglandin I2 analogs in conscious newborn lambs. Multiplex, quantitative, real-time PCR assay for cytomegalovirus and human DNA. A two-dimensional, biomechanical computer model was developed, using the software package Working Model(TM), to simulate the postural control of seated individuals. Most tests have better specificity when they are performed for patients in whom infection is suspected clinically rather than when they are used as screening tests. These results indicate that dopamine, presynaptically acting on dopamine D1 receptors, increases the frequency of spontaneous EPSCs via intracellular protein kinase A and protein kinase C signaling pathways in pyramidal cells of layers V-VI of the prelimbic cortex. Exon swapping partially reversed the channel sensitivity to deltamethrin. T-cell ALL samples from four of five children overexpressed H-ras, while three of five patient samples overexpressed the third exon of c-myc when compared to normal lymphocytes and normal T-cells. The importance of subjective facial appearance on the ability of anesthesiologists to predict difficult intubation. The method potentially could be used to determine polar and trace-level nucleosides and nucleobases in ginkgo seeds. AtT-20 corticotrophs express B-Raf, as do other cells allegra generic dosing in which cAMP stimulates MAPK.

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