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Alertec (Modafinil)
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Alertec

Alertec is used to treat excessive sleepiness caused by certain sleep disorders. This includes narcolepsy, sleep apnea, and shift work sleep disorder. Alertec can be taken every day depending on the condition for which this medication is being used for.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

Similar Products:
Robaxin, Cytoxan, Crestor, Cialis, Catapres, Symmetrel, Compazine, Periactin, Betaone, Vominil, Lexis, Nebilet, Helkoss,

Also known as: Modafinil

Description

How you take Alertec may depend on what you’re taking it for.

Timing

If you’re taking Alertec to reduce daytime sleepiness due to narcolepsy or sleep apnea, you’ll take it in the morning.

If you’re taking Alertec for shift work sleep disorder, you’ll likely take it one hour before your work shift.

Alertec will keep you awake for several hours, so you shouldn’t take it too close to your bedtime.

Taking Alertec with food

You can take Alertec with or without food. If the drug upsets your stomach, taking it with food might reduce this side effect. However, if you take it with food, Alertec might take slightly longer to start working.

Can Alertec be crushed?

Alertec tablets should not be crushed or split. If you’re having trouble taking Alertec, talk to your doctor or pharmacist about options that can make swallowing the tablet easier.

Dosage

Usual Adult Dose for Narcolepsy:

200 mg orally daily in the morning

Usual Adult Dose for Obstructive Sleep Apnea/Hypopnea Syndrome:

200 mg orally daily in the morning

Usual Adult Dose for Shift Work Sleep Disorder:

200 mg orally daily one hour prior to the start of the work shift

Usual Pediatric Dose for Attention Deficit Disorder:

Not FDA approved. Reports of serious dermatologic adverse effects and psychiatric events has resulted in the FDA's Pediatric Advisory Committee unanimously recommending that a specific warning against the use of modafinil in children be added to the manufacturer's labeling; use only if first- and second-line treatments have failed and the benefits outweigh the risks. Children less than 30 kg: 200-340 mg once daily Children more than 30 kg: 300-425 mg Randomized, double-blind, placebo-controlled pediatric studies have utilized an 85 mg film-coated tablet (currently not commercially available) to provide these dosages. All studies utilized a titration method but varied the length of titration (3 weeks vs 7-9 days); clinical improvement was noted earlier in the shorter titration period.

Detailed Alertec dosage information

Overdose

If you overdose Alertec and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Alertec are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid other dangerous activities until you know how Alertec will affect your level of wakefulness.

Avoid drinking alcohol while taking modafinil.

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Influence of hepatopetal flow of the retroportal artery on efficiency of repeated hepatic arterial infusion chemotherapy. Any restrictions were caused by a limitation in dorsiflexion, whereas plantarflexion was for all gait conditions sufficiently provided. We show that treatment of cell-free virus with PLWUV could inactivate viral replication without abolishing the ability of the virus to infect cells. Molecular analysis of the triticale lines with different Vrn gene systems using microsatellite markers and hybridization in situ. Our aims were to study the efficacy of a new class of metal stents covered with a membrane with regard to fistula occlusion and lumen patency. It quantifies vascular compromise reflecting the severity of diabetic retinopathy. Distribution of phthalates, pesticides and drug residues in the dissolved, particulate and sedimentary phases from transboundary rivers (France-Belgium). We examined the association between body size at birth and intake of foods and macronutrients in adulthood. CPT1A silencing reduced these processes and depleted endothelial cell stores of aspartate and deoxyribonucleoside triphosphates. Endoscopic retrograde cholangiopancreatography (ERCP) indicated chronically changed pancreatic ducts of varying diameter and stenosis, as well as a filiform distal stenosis of the common bile duct.

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In the Ishikawa orthoptopic murine model, treatment with GSK2256098 resulted in lower tumor weights and fewer metastases than mice inoculated with Hec1A cells. Immediate hypersensitivity to iodinated media might increase in the near future with the use of divalent molecules. Susceptible nonusers liked the tobacco advertisements at a level that was significantly greater than that of the nonsusceptible nonsmokers and comparable to that of the users. To report our experience with late vitritis associated with keratoprosthesis (KPro). Improving the prediction of protein secondary structure in three and eight classes using recurrent neural networks and profiles. Further, the acclimation to EHL1200 was associated with an extremely high chlorophyll a/b ratio (3.97), a more than doubled xanthophyll cycle pool (VAZ) and a six-fold higher de-epoxidation state of the xanthophyll cycle pigments as compared to barley grown under 25 mumol m(-2) s(-1) (LL25). Our studies indicate that the glucoincretin hormone GLP-1 is able to constitute biphasic insulin release in the immature beta-cell, possibly as the result of cAMP-mediated priming of the glucose sensor mechanism. Population source was a level I trauma center registry for years 2007-2009. Biological evaluation of epoxy analogs of 1 alpha,25-dihydroxyvitamin D3. We conclude that mandatory single embryo transfer is not justified and that a number of countries should reconsider their current embryo transfer policy.

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Using the hMeDIP-chip analysis and validation by quantitative RT-PCR (RT-qPCR), we identified the differentially hydroxymethylated regions that are associated with SLE. The purpose of the present study was to further explore the accuracy of the PlusOptix A09 photoscreener in children with ametropia (myopia or hyperopia). At this writing, the clinical effect of nicotine on spinal fusion has not been fully clarified. During the data analysis of photographs, discussions, and interviews, the women with HIV shared the importance of showing their faces. To use classification algorithms to classify swallows as safe, penetration, or aspiration based on measurements obtained from pharyngeal high-resolution manometry (HRM) with impedance.

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The small intein in the Thermoplasma A-ATPase is closely related to the endonuclease containing intein in the Pyrococcus A-ATPase. We conclude that oral administration of immune milk leads to significant improvements of symptoms and signs in OSF patients. In this paper, it is the first time that a new model based on micron X-ray computed tomography (CT) has been proposed to simultaneously consider both the separation of matrix and pore and the distribution of mineral components. Cryptococcosis is a serious fungal disease in patients with AIDS or other defects in T-cell-mediated host defenses. To demonstrate how changes in tobacco flue-curing practices in the 20th century increased levels of tobacco-specific nitrosamines (TSNAs) in tobacco smoke. The study revealed variations in the utilization, preference and opinion for further revision of the DSM and the ICD classificatory systems in East Asia. Serologic cross-reactivity between Anaplasma marginale and Anaplasma phagocytophilum. Catheter preservation is rarely possible in cases of Staphylococcus aureus bloodstream infection because of frequent relapse and the risk of endocarditis, osteomyelitis and septic arthritis. There have been few studies of barriers to acceptance of influenza immunization among medical residents. Characterization of extracellular polymeric substances (EPS) from periphyton using liquid chromatography-organic carbon detection-organic nitrogen detection (LC-OCD-OND).

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Effects of web-based psychoeducation on self-efficacy, problem solving behavior, stress responses and job satisfaction among workers: a controlled clinical trial. Comparative study on the effects of different therapeutic methods in preventing and treating nonalcoholic fatty liver in rats. The mark found on the head of a subordinate animal may, in the future, be used to identify the dominant animal of the social group, who placed the mark. Segmental resection of the upper arm and replantation of the distal segment to the proximal humerus as an alternative to shoulder disarticulation for a large tumor of the humerus is reported. However, FBA leads to incorrect predictions in situations where regulatory effects are a dominant influence on the behavior of the organism.

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HSP70 and HSP90 Differentially Regulate Translocation of Extracellular Antigen to the Cytosol for Cross-Presentation. Tobacco tax and the illicit trade in tobacco products in New Zealand. Catheter fracture and cardiac migration are rare but known complications. The benefits of the method, however, need further scientific evaluation. Molecular determinants of Au(CN)(2)(-) binding and permeability within the cystic fibrosis transmembrane conductance regulator Cl(-) channel pore.

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Medically assisted alcohol withdrawal remains consensual and effective. In five llamas treated subcutaneously with 25 per cent ivermectin sustained-release microspheres at 1500 microg/kg, the median Cmax was 5 ng/ml and the median AUC was 224 ng x day/ml. To determine if the absence of GLP-2 was a general feature of stomach proglucagons we isolated and characterized proglucagon cDNAs from the stomach and the pancreas of the dog, a mammal that expresses the proglucagon gene in the stomach. curvatum is a pathogen that can be readily isolated from the vitreous. It is proposed to designate it Rtp-3 with three alleles: Rtp-3a, Rtp-3b, and Rtp-3c.

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Anesthetic effects changeable in habitual drinkers: Mechanistic drug interactions with neuro-active indoleamine-aldehyde condensation products associated with alcoholic beverage consumption. Twenty one representative Computed Tomography facilities at different hospitals and clinics. The first chemical synthesis of phosphorylated ubiquitin and of Lys63-linked diubiquitin at the proximal, distal or both ubiquitins is reported. The coded data generated themes and we present the themes in qualitative narration. Finally, exposure of tidally entrained oysters to saxitoxin (STX)-producing alga Alexandrium minutum induced a dose effect response in oysters by first altering Cgcry1 expression and then the behavior of oysters with increasing concentrations of toxins. Nox2 mediates skeletal muscle insulin resistance induced by a high fat diet. rHIgM22 enhances remyelination in the brain of the cuprizone mouse model of demyelination. It has a significant economic impact, and several Babesia motasi-like isolates have been recently shown to be responsible for ovine babesiosis in this country.

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Finally, information is provided about the advantages and disadvantages of using all three antigens in the diagnosis of cancer. Here we present an efficient technique for quantitative detection of microsatellite alleles, using a post-PCR fluorescence-labeling procedure and multiplexed analysis. Despite the advances in sequencing speed, the computational discovery of structural variants is not yet standard. Exogenous administration of CCK-2 receptor agonists, such as cholecystokinin-tetrapeptide and pentagastrin, provoke panic attacks in man. Thalamic projections to the prefrontal cortex (PFC) are critical for cognition, and disruptions in these circuits are thought to underlie the pathophysiology of schizophrenia.

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The abundance of proteins involved in fundamental biological processes, cellular component organisation and stress responses were significantly altered in inoculated root samples. Many patients are not well-informed, do not want to deal with dying or would like to delegate decisions to relatives and physicians. It is considered that not only Th1 but also Th2 cells participate in the pathogenesis of murine photocontact dermatitis to ketoprofen. The important role of the immune system and inflammation in the pathophysiology of heart failure (HF) is becoming increasingly appreciated. Our sample data came from a population of one million individuals randomly selected from the Taiwan National Health Insurance Database, 1998 to 2011. No-reflow frequently complicates vein graft interventions but can be treated with vasoactive agents such as calcium channel blockers, adenosine, and nitroprusside. These new responsibilities have implications for relations with staff inside the organisation and, in particular, with clinicians, as well as adding to the overall public accountability of chief executives. Anastomosis incongruence was avoided by a plication procedure never described before. The patient underwent complete surgical excision and is disease free 7 months later.

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In case of delayed surgery, MRI and MRS should be performed in order to exclude revascularization and to establish the fatty degeneration of the meningioma. Subtyping achalasia by high-resolution manometry (HRM) is clinically relevant as response to therapy and prognosis have shown to vary accordingly. Here we describe the construction and use of a glass probe coupled to a piezo-electric actuator for stimulating hair bundles, including the basic technique for positioning of cipro 250 mg bid the stimulating probe onto the hair bundle. Auditory perception in auditory neuropathy: clinical similarity with auditory verbal agnosia. Hookworm transmission seems to occur within, rather than between villages in Champasack province.

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In persons born preterm, in the absence of perinatal brain injury on visual inspection of MRI, widespread alterations in regional brain tissue volumes and microstructure are present in adolescence/young adulthood. STAT1 and STAT3 mediate thrombin-induced expression of TIMP-1 in human glomerular mesangial cells. Low prestimulus theta produced greater NoGo N2 and Go P3, and reduced NoGo P3 responses, each of these suggesting appropriately enhanced cognitive processing. Schistosomiasis haematobia also appears to negatively influence fertility, and is particularly associated with female infertility. Outcome analysis of patients with squamous cell carcinoma of the head and neck and hepatitis C virus. We studied 10 patients for visible alternations in brain metabolism and compared the results to healthy controls. During the clinical course of methanol poisoning ECG revealed pathological Q wave and ST segment elevation in leads II, III, aVF, without increased cardiac enzymes activity. Postoperative pulmonary and renal complications are frequent in patients undergoing lung surgery.

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Participants were 354 women with provoked vestibulodynia and their partners. Heat sensitivity of endospores increased markedly in food samples supplemented with enterocin AS-48: inactivation of endospores was achieved by heating for 1 min at 90 degrees C in boiled rice or at 95 degrees C in rice-based gruel. Every child received RAGT with the Lokomat complementing a multidisciplinary rehabilitation program. The repeatability and variability of electrical impedance tomography enalapril dose in dogs indices of pharyngeal transit time in normal adults. Rats exhibit asymmetrical retention functions for hedonic and nonhedonic samples in many-to-one symbolic delayed matching to sample. To report the closure of oroantral communications with the pedicled buccal fat pad in a series of patients, and to determine the level of patient satisfaction after the surgery.

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These data strongly suggest that Src through its SH2 domain interacts with bleached rhodopsin and arrestin either directly or indirectly. Beneficial effects of N-acetylcysteine and N-mercaptopropionylglycine on ischemia reperfusion injury in the heart. Analysis of a phosphorylcholine-based polymer coating on a coronary stent pre- and post-implantation. pulicicidum, is proposed to accommodate this widespread organism. Increased pain catastrophizing associated with lower pain relief during spinal cord stimulation: results from a large post-market study. This study of specific community shifts together with functional parameter analysis has potential as a tool for relating functional instability (such as operational failures) to specific-bacterial community shifts. Hence, the major challenge in drug development and delivery for the neurological diseases is to design non-invasive nanocarrier systems that can assist controlled and targeted drug delivery to the specific regions of the brain. Two different mind-body interventions helpful for treating these problems are Mindfulness-Based Cancer Recovery (MBCR) and Tai Chi/Qigong (TCQ).

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This sample of homeless youths with mental illness had low education, high rates of substance use disorders and victimization, and problems accessing services. The 14 parathyroid adenomas with significant Tc-99m MIBI uptake in delayed 2hr images revealed negative P-gp expression, but the 2 adenomas without significant Tc-99m MIBI uptake, as well as normal parathyroid and normal thyroid specimens, revealed positive P-gp expression when evaluated by IHC. The most common benign liver lesions, such as hemangioma, bile duct cyst, and FNH, reveal characteristic cross-sectional imaging features that allow an accurate diagnosis. We investigated this role further by examining the effects of excitotoxic lesions of the basolateral amygdala on the ability of rats to use instrumental outcomes to direct responding (the differential outcomes effect) and on the ability of Pavlovian cues to modulate instrumental performance based on shared outcomes (reinforcer-selective Pavlovian-to-instrumental transfer). Acknowledging Errors: Advanced Molecular Replacement with Phaser. This investigation studies the effect of the shot-blasting treatment on the cyclic deformation behavior of a commercially pure titanium, with two microstructures: equiaxed and acicular. Vitamin D stimulation of calcium- prilosec heartburn medicine side effects dependent adenosine triphosphatase in chick intestinal brush borders. The small size, simplicity, high output power, long-term reliability make external cavity quantum cascade lasers (EC-QCLs) the promising spectroscopic sources for developing analytical instrumentation. Pelvic Floor Reconstruction After Radical Prostatectomy: A Systematic Review and Meta-analysis of Different Surgical Techniques. Our goal in this study was to determine if exposing rabbit fetus to nicotine altered the cardiac conduction system of newborn kittens in a manner susceptible to cause SIDS.

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These results suggest that aFGF may play an important role in cochlear recovery after acoustic injury. The graft is percutaneously placed through a femoral stab incision, and each strand is then passed deep to the iliotibial band, emerging through each tibial stab incision. Soccer improves fitness and attenuates cardiovascular risk factors in hypertensive men. Taken together, this information supports the hypothesis that Rett syndrome is a genetic disorder of synapse development, especially synapses that use glutamate and GABA as neurotransmitters. Recent results suggest there are fundamental differences in antigen recognition by alpha beta and gamma delta T-cell receptors, which might underlie possible differences in function between these two types of T cell. This is the first trade-off analysis of the different PDE5Is currently available. As ultrasonographic evaluation during laparotomy revealed multiple liver metastases, a hepatic artery infusion catheter was inserted into the proper hepatic artery. Costunolide and dehydrocostus lactone were isolated from an extract of mokko (Saussurea lappa Clarke) as inhibitors of killing activity of cytotoxic T lymphocytes (CTL). Rapid and early detection of Salmonella serotypes with hyperspectral microscopy and multivariate data analysis.

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Der f 2 is a major mite allergen composed of 129 amino acid residues. Azithromycin, a member of the new azalide class, has to date produced fewer clinically significant interactions than other azalides with any agent that is cleared through ultram drug class the CYP3A system.(ABSTRACT TRUNCATED AT 250 WORDS). Clinical guidelines for the management of epilepsy in adults with an intellectual disability. Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. The present study used the stimulus onset delay paradigm to investigate eye movement control in reading and in scene viewing in a within-participants design.

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After 24 h of cultivation, the cell concentration in the capsule core-liquid reached 222 microg/mm3 on a dry weight basis, which was 1.4 times as large as that in the core of double-layered alginate beads, i.e., alginate-coated alginate-gel beads. The purification and properties of phosphonoacetate hydrolase, a novel carbon-phosphorus bond-cleavage enzyme from Pseudomonas fluorescens 23F. Results were pooled across studies using quantitative synthesis. The changing trends and profile of pneumocystosis mortality in the United States, 1999-2014. The present study demonstrates that modeling of time interval of maximum proliferative activity of tumors cells increases information efficacy and reliability of the analysis of dividing cell patterns using Cell-IQ technology. Antiplasmodial, anti-complement and anti-inflammatory in vitro effects of Biophytum umbraculum Welw.

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The study subjects were 33 dogs and 31 cats with no gross corneal pathology, which had been euthanised by pentobarbital overdose for reasons unrelated to this project. Parathyroid adenomas: a potential source of pitfalls for thyroid FNA cytology. Participation in formative quizzes was correlated to summative exam scores. Protein profile alterations following exposure to cadmium were examined in marine alga Nannochloropsis oculata through proteomic analysis. An observational study suggested glibenclamide decreased the incidence of fatal myocardial infarction and development of ventricular fibrillation in patients suffering from acute myocardial infarction. We interviewed 56 consecutive PD patients and 59 age-matched healthy controls concerning sleep disorders and depression. In a case series of peri-implant fractures in femurs with plate/screw constructs, we aimed to assess similarities with classical AFFs and how their location may have implications for the pathogenesis and management of AFFs. The intrauterine pressure catheter was left in place during cesarean delivery, and the position was documented. Intraabdominal anastomotic pseudoaneurysms continue to be a late complication of aortic reconstructive procedures.

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