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Alfabond (Calcitriol)
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Alfabond

Alfabond is an active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia. Alfabond is a biologically active calcitrophic hormone with anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities.

Other names for this medication:
Alcee, Alfabond, Alfacip, Alfarich, Aristrol, Biocitral, Calasto, Calbec, Calcibest, Calcicare, Calcirol, Calcit, Calday, Caldikind, Caldix, Calfa, Caltive, Caltop, Carcal, Coecoral, Denscal, Devita, Duracal, Estovon, Lctrol, Minroset, Netxod, Novadee, Ostriol, Primacal, Qpcal, Refirm, Rical, Rockbon, Roical, Septriol, Sorvate, Sunmic, Trolec, Zaxial

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Estrace, Terramycin, Deltasone, Buspar, Micardis, Invasc, Amtran, Klaritpharma, Kevtram, Abend, Divalin, Glimli, Thiazprine,

Also known as: Calcitriol

Description

Generic Alfabond is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfabond are intestine and bone. Generic Alfabond receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfabond may also act on the kidney and the parathyroid glands. Generic Alfabond is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfabond has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfabond, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfabond in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfabond produces other independent beneficial effects. Alfabond is also known as Calcitriol. Generic Alfabond treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfabond is Calcitriol. Brand name of Generic Alfabond is Alfabond.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Alfabond. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Alfabond and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alfabond are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Trait procrastination among dental students in India and its influence on academic performance. We analyze data from 417 children of centenarians and 560 neighborhood controls without family history of longevity in China (all participants aged 60-80) using ordered logit regression models. Alterations in steroid hormone production by porcine ovarian granulosa cells caused by bisphenol A and bisphenol A dimethacrylate. Thus, a specific primary sequence or zippering beyond the SNARE domains is not a prerequisite for fusion. When expressed, 2a polymerase colocalizes in these spherules, which become the sites of viral RNA synthesis and retain negative-strand templates for positive-strand RNA synthesis. The results imply that there is substantial opportunity for natural or artificial selection to act on quantities of stored lipid and carbohydrate, and that the response to selection is likely to be in part mediated by changes in the kinetics of the enzymes targeted in this study. This research examines the types of social support behaviors that the opioid-dependent individuals consider helpful and explores whether attachment style (i.e., secure, ambivalent, or anxious attachment) was a determining factor in whether social support was perceived as helpful. Patients attending psychiatric outpatient service at a mental hospital were asked specifically about various treatment facilities utilized by them before coming to the hospital and the reasons thereof.

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We present DNA sequence evidence from the 12S and 16S rRNA mitochondrial genes, and from the nuclear gene that codes for the eye lens protein, alpha A-crystallin. The heart surface source model appears to provide a basis for relating heart surface potentials to the distribution of cellular action potential. First-field HLA genotyping was performed by polymerase chain reaction sequence-specific priming and/or oligonucleotide methods. Individuals with migraine may experience barriers to receiving minimal appropriate care. We suggest that the failure of cyt c-/- cells to release Smac/DIABLO after recruitment of Bax to mitochondria represents an extreme manifestation of some inherent difference in the regulation of release of these two proteins from mitochondria. Different features have been associated with low susceptibility to HIV type 1 (HIV-1) infection in exposed seronegative individuals. UV-induced immunosuppression is via the action of regulatory T cells (Tregs).

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The mechanisms responsible for these effects, however, are still poorly understood. One hundred and ninety-one Aboriginals and 159 non-Aboriginals were recruited between April 2008 and September 2009. Adolescents with chronic pain often report inattention and poor memory. Catheterization of the pulmonary artery in regional chemotherapy for primary or metasatic localizations of trophoblastic tumors. However, the association between microbiota and flavours and flavour-producing core microbiota are still poorly understood.

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Fractionation of DNA on columns of poly-L-lysine supported on kieselguhr. Collectively, these results highlight our disturbingly limited knowledge of this crucial issue but also support the idea that changing species interactions are an important cause of documented population declines and extinctions related to climate change. Randomised controlled trials, comparative studies, and cohort studies were included. Logistic regression models indicate that truth ad awareness is significantly associated with increases in targeted anti-tobacco attitudes as well as reduced intentions to smoke over time, holding constant baseline attitudes and intentions. Approximately 600 bp of the bacterial 16S rRNA gene (E341F-E907R) was amplified via polymerase chain reaction using universal primers, and clone libraries were constructed. Synthetic peptide analogs derived from bcr/abl fusion proteins and the induction of heteroclitic human T-cell responses. Failure to accomplish this program results in feeling of unrefreshing sleep and tiredness in the morning. Discussion focused on the relations of these findings to hypotheses concerning the role of impulse control in antisocial behavior. Survey of the literature suggested that hereditary factors might be involved in the what happens if you take 20 mg of zyrtec familial occurrence of testicular cancers although there was no definitive evidence. phaseolicola LR700 cosmid library was screened with Tn5-containing EcoRI fragments cloned from nonpiliated mutants.

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