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Almazine (Lorazepam)
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Almazine

Almazine is a benzodiazepine medication. It is used to treat anxiety disorders, trouble sleeping, active seizures including status epilepticus, alcohol withdrawal. It is used to treat chemotherapy induced nausea and vomiting, as well as for surgery to interfere with memory formation and to sedate those who are being mechanically ventilated. While it can be used for severe agitation, midazolam is usually preferred. It is also used, along with other treatments, for acute coronary syndrome due to cocaine use. It can be given by mouth or as an injection into a muscle or vein. When given by injection onset of effects is between one and thirty minutes and effects last for up to a day.

Other names for this medication:
Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Calmese, Dulozep, Larosh, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac

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Micardis, Plavix, Temovate, Moduretic, Epivir, Panadol, Parlodel, Celebrex, Symbicort, Amvasc, Apsolam, Rifafour, Glucut, Azold, Alprine, Fungixit, Pentorex,

Also known as: Lorazepam

Description

Lorazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to treat a seizure emergency called status epilepticus. Lorazepam injection is also used as a sedative to help you relax before having surgery.

Dosage

Usual Adult Dose for Anxiety:

Initial dose: 2 to 3 mg orally per day, given 2 to 3 times per day Maintenance dose: 1 to 2 mg orally 2 to 3 times a day Comments: -The daily dosage may vary from 1 to 10 mg/day. -The dosage should be increased gradually when needed to help avoid adverse effects. -When higher dosage is indicated, the evening dose should be increased before the daytime doses. -Use of anxiolytic agents is typically not needed to treat anxiety/tension associated with the stress of everyday life. -Clinical studies have not evaluated this drug for efficacy in long-term treatment (e.g., greater than 4 months). Uses: -Management of anxiety disorders -Short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms

Usual Adult Dose for Insomnia:

2 to 4 mg orally once a day at bedtime Comments: -The dosage should be increased gradually when needed to help avoid adverse effects. -Clinical studies have not evaluated this drug for efficacy in long-term treatment (e.g., greater than 4 months). Use: Management of insomnia due to anxiety of transient situational stress

Usual Geriatric Dose for Anxiety:

Older or debilitated patients: -Initial dose: 1 to 2 mg orally per day, given in divided doses Comments: -The dosage should be increased gradually when needed to help avoid adverse effects. -The daily dosage may vary from 1 to 10 mg/day. -When higher dosage is indicated, the evening dose should be increased before the daytime doses. -Use of anxiolytic agents is typically not needed to treat anxiety/tension associated with the stress of everyday life. -Clinical studies have not evaluated this drug for efficacy in long-term treatment (e.g., greater than 4 months). Uses: -Management of anxiety disorders -Short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms

Detailed Almazine dosage information

Overdose

In cases of a suspected Almazine overdose, it is important to establish whether the patient is a regular user of Almazine or other benzodiazepines, since regular use causes tolerance to develop. Also, one must ascertain whether other substances were also ingested.

Signs of overdose range through mental confusion, dysarthria, paradoxical reactions, drowsiness, hypotonia, ataxia, hypotension, hypnotic state, coma, cardiovascular depression, respiratory depression, and death.

Early management of alert patients includes emetics, gastric lavage, and activated charcoal. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil.

Patients are ideally nursed in a kind, nonfrustrating environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions. If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues. Opportunistic counseling has limited value here, as the patient is unlikely to recall this later, owing to drug-induced anterograde amnesia.

Storage

Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Almazine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Almazine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Almazine should be avoided in people with:

Allergy or hypersensitivity – Past hypersensitivity or allergy to Almazine, to any benzodiazepine, or to any of the ingredients in Almazine tablets or injections

Severe respiratory failure – Benzodiazepines, including Almazine, may depress central nervous system respiratory drive and are contraindicated in severe respiratory failure. An example would be the inappropriate use to relieve anxiety associated with acute severe asthma. The anxiolytic effects may also be detrimental to a patient's willingness and ability to fight for breath. However, if mechanical ventilation becomes necessary, Almazine may be used to facilitate deep sedation.

Acute intoxication – Almazine may interact synergistically with the effects of alcohol, narcotics, or other psychoactive substances. It should, therefore, not be administered to a drunk or intoxicated person.

Ataxia – This is a neurological clinical sign, consisting of unsteady and clumsy motion of the limbs and torso, due to failure of gross muscle movement coordination, most evident on standing and walking. It is the classic way in which acute alcohol intoxication may affect a person. Benzodiazepines should not be administered to already-ataxic patients.

Acute narrow-angle glaucoma – Almazine has pupil-dilating effects, which may further interfere with the drainage of aqueous humor from the anterior chamber of the eye, thus worsening narrow-angle glaucoma.

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The magnitude of changes in the indicators of endothelial dysfunction and in the markers of endothelial damage depends on the severity of hepatic damage. Anti-inflammatory actions of a micronized, purified flavonoid fraction in ischemia/reperfusion. To characterise the metabolic profile of women with polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD) and to determine whether circulating androgens differ in PCOS women with NAFLD compared to PCOS subjects without NAFLD. Few studies have addressed challenges of diagnosis and treatment of sexually transmitted diseases (STDs) within correctional facilities. Preclinical investigations with murine models were assessed to analyze whether the current evidence support clinical trials. Owing their diverse effects and inconclusive results from different in vitro studies, the mechanism of their action has not yet been fully understood and the correlation of effects with chemical structure is not conclusive at the moment. In the treatment of respiratory distress syndrome, the anti-inflammatory response of surfactant may thus depend upon the specific preparation of the surfactant. The dispensability of the MnSOD enzyme may be due to the activities of two other SOD enzymes, a highly expressed iron-type superoxide dismutase and a much less abundant copper/zinc type, that were also detected in C. The transmitted time-spectra associated to their Fast Fourier Transforms are used to detect embedded objects within diffusive slab media. There is a close correlation between binding constants (KD) for inhibitors determined by analysis of competitive displacement of 125I-HYP from receptor, and apparent affinities (Ki) for inhibition of adenylate cyclase.

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Under these specific experimental conditions, pH did not have a significant effect on conidial germination. Magnetic nanoparticle hyperthermia is also being studied as an adjuvant to conventional chemotherapy and radiation therapy. Patient 2 was treated with topical natamycin, topical amphotericin, and 200 mg oral voriconazole twice daily for 1 month with residual scarring and a best-corrected visual acuity of 20/25. Toxicity and exposure functions will be fully characterised, producing distributions of predicted impact and quantifying the variability and uncertainty. Clinical and histopathologic characteristics, specifically nodular and diffuse LPHD, and treatment groups were assessed by overall and relapse-free survival, patterns of relapse, and causes of death. The role of Fc gamma receptor (FcgammaR) I and II in modulating the expression of TIM4 in DCs was investigated.

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In the series of events in the metastatic stage, tumor cells leave the primary tumor in breast and travel to distant sites where they establish secondary tumors, or metastases. Effects of Pictorial Warning Labels for Cigarettes and Quit-Efficacy on Emotional Responses, Smoking Satisfaction, and Cigarette Consumption. occlusion) and (b) support the notion that infants are more likely to give evidence of object individuation when they need to reason about one kind of event (i.e. Improvement of the illness was monitored by serial ABG analysis and breathing pattern parameters over one week. This part-based effect was not influenced by the spatial distance between the parts, ruling out a simple spatial attention interpretation of our results. Application of a novel interferometric method to investigate the relation between lipid layer thickness and tear film thinning.

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PAH in autoimmune diseases could be potentially fatal with characteristic manifestations. They developed clinical manifestations of encephalitis around day 17 post transplant. These areas are thought to play an important role in emotional processing in the normal brain. TIP120A is thought to be a unique global transcription factor that can interact with TBP and can stimulate all classes of eukaryotic transcription. One- and two-dimensional imaging experiments have been conducted on some solid samples, confirming the improved performance and revealing a TREV-16TS adjustment parameter that is critical for the successful echo FT imaging.

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To investigate the correlation between angiogenesis and tumor growth pattern as well as the lymph node metastasis to reveal the significance of vascularity in the early stage of gastric cancer. In vitro studies have indicated that retroviral nucleocapsid (NC) protein facilitates both DNA synthesis by reverse transcriptase (RT) and annealing of the nascent DNA with acceptor template. In cattle, glucagon staining was observed at day 25 and insulin staining from day 26. Commonly approved diagnostic criteria were applied, and secondary cardiomyopathies were carefully excluded. High incidences of diabetes and cataracts were found to be associated with herpes zoster infection. Consequently, the H19 gene is exclusively transcribed from the maternal allele. These results suggest that blockade of the renin-angiotensin and sympathetic nervous systems in heart failure may be beneficial in part as a result of improved sodium excretion. Preceed is an effective method of treating refractory ascites in the hemodialysis patient.

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Vascular access for hemodialysis using bovine heterografts and polytetrafluoroethylene conduits. In in vitro studies, we firstly explored whether ioversol signal is pH-dependent, and calculated the function equation between the CEST effects of ioversol and pH values, in the range of 6.0 to 7.8, by a ratiometric method. The brain is a well-organized, yet highly complex, organ in the mammalian system. Free NTA was degraded at a specific rate of 0.7 mM (gMLSS)(-1)h(-1), while Fe(III)-NTA was degraded at a specific rate of 0.37 mM (gMLSS)(-1)h(-1). Mutagenesis resources targeting every gene of the genome and the importance of inbred genetic background are discussed. Patients with EH, RH and WCH had increased plasma levels of PAI-1, tPA, tPA/PAI-1 complex and fibrinogen compared with controls. How culture influences perspective taking: differences in correction, not integration. These cytokines determine the pattern of hypothalamic-pituitary secretion that characterizes infection. We conducted a similar study using the cubozoan jellyfish Carybdea marsupialis, concentrating not only on the adaptive features of multiple pacemaker networks but also on the mechanism of pacemaker interaction. Imaging techniques have only recently been utilized in combination with clinical observation to objectively quantify psoriasis severity and evaluate therapeutic response.

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ManB isolated from Streptomyces coelicolor was shown to have both phosphomannomutase and phosphoglucomutase activities. Caring for Families at the Limits of Viability: The Education of Dr Green. Antibodies to the Golgi complex and the rough endoplasmic reticulum. Modified Mathieu s procedure is an effective method, to repair the anterior hypospadias without or with minimal chordee. DOX treatment caused disorganization of myocardial tissue which was restored in animals treated with GTE along with DOX. To study the changes in the mRNA expression of insulin-like factor 3 (INSL-3) in the testis of mouse models of flutamide-induced cryptorchidism. This article describes the physiological mechanisms by which the mind affects the body, reviews research substantiating the link between psychosocial processes and immune functioning, and examines the limited research that has addressed the religion-PNI relationship. Permanent nonunion of the humeral shaft leaves the patient with severe disability.

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Cardiopulmonary bypass with hypothermic circulatory arrest can safely be used in the treatment of complex adult coarctation. The influence of corticosteroids on flavin nucleotide biosynthesis in rat liver and kidney. Hawaii Sero-Positivity and Medical Management (HSPAMM) program participants from January 1989 to November 2002. Recent findings that free fatty acids, glucose, sulfonylurea, and amylin cause beta-cell apoptosis in vitro suggest that programmed cell death may also be involved in the pathogenesis of type 2 diabetes. Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat. Radiotherapy using a direct anterior field proved effective palliation for this disease site. Intraovarian actions of granulosa cell-derived activins include the promotion of granulosa cell proliferation and upregulation of FSH receptors, P450arom, oestrogen synthesis, granulosa cell LH receptors and enhancement of oocyte maturation.

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We examined 9350 mothers and infants participating in the first wave of the Early Childhood Longitudinal Study, Birth Cohort in 2001. The pharmacokinetics and pharmacodynamics of drugs in the CSF, when administered by the intravenous and the intrathecal route, are also reviewed. There is experimental evidence indicating that autoantibodies belonging to different immunoglobulin G (IgG) subclasses may have different functional activity. This is especially important in the rapidly changing landscape of the pharmaceutical industry. We first diagnosed the dermal manifestation as atypical generalized zoster, however, the other clinical findings could not be explained by VZV infection only. A literature search via PubMed, EMBASE and CNKI (China National Knowledge Infrastructure) databases was conducted. Polymorphisms of VDR gene and risk of gastric cardiac adenocarcinoma in Chinese population. Here, we studied the effects of cryptotanshinone (CTS) on MGs in vitro and in vivo, and explored the underlying mechanisms. General and Ethnic-Biased Bullying Among Latino Students: Exploring Risks of Depression, Suicidal Ideation, and Substance Use. Brief report: the cochlear microphonic as an indication of outer hair cell function.

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Analysis of variance between subgroups within the groups of volleyballers aged 14-15 and those aged 16-17 showed the results on all motor tests to improve with the increase in situation performance, which was especially pronounced in the tests assessing explosive strength and agility. Build-up of contemporary medical and preventive technical occupational health care. The lifetimes are determined from the line widths of the resonant dips appearing in the specular reflection spectra. Comparison of As removal performance by graphene/iron-based material. People with diabetes have higher risk of cardiovascular mortality and higher C-reactive protein (CRP) levels than people without diabetes.

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Forty-seven patients with newly diagnosed T1 or T2 breast cancer underwent injection of 99mTc-labeled cysteine-rhenium colloid followed by lymphoscintigraphy. Complementation of the mutant with an intact hexAB fragment restored lethality in mice but not in chickens. This paper examines the main aspects of nursing care for brain-injured patients. The non-protein-coding transcriptional output of the cell is far greater than previously thought. The suggestion is that 24 hour visiting should apply to fathers, thus circumventing the problems with providing accommodation for them. In 5 patients an extensive defect of the intestine with two atresias of the small and large bowel was noted. Propranolol and pyrogen effects of shivering and nonshivering thermogenesis in rats. In contrast, subjects wearing impregnated BDU had about 200-fold higher exposure levels.

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These findings indicate that child restraint policies and educational approaches are urgently needed in China. This study demonstrates the crucial role of ligands in the regulation of homodimeric versus heterodimeric association glucophage xr 500mg tablets state of RXR in the NR signalling pathways. Within-day fluctuations in serum bile-acid concentrations among normal control subjects and patients with hepatic disease. MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K/Akt signaling by targeting PTEN. An overview of activities in the field of Process Analytical Technologies (PAT) at the Universities of Applied Sciences in Switzerland is presented. Obesity is associated with an increased rate of cardiovascular disease and risk factors. Carcinoma colon presenting as paraneoplastic sensorimotor neuropathy.

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The synthesis of (22R)- and (22S)-5beta-cholestane-3alpha,7alpha,12alpha,22,25-pentols is described. We have generated transgenic (Tg) mice with muscle-specific overexpression of full-length C3 or C3 isoforms, which arise from alternative splicing, to test whether stable expression of C3 transgenes could occur in vivo. The minimum, and maximum intensities, and their differences revealed a linear relationship to the angle of inclination of fibers. This communication presents a method for estimating the median lethal dose, based on a modification of the beta-binomial distribution. In this post hoc analysis of patients with previously untreated HIV-1 infection receiving raltegravir plus tenofovir-emtricitabine, generally comparable results were achieved across sex and racial subgroups. Treatment three times for 4 hours showed a superior angiogenic effect also when compared with short initial applications (6-hour and 12-hour groups). To clarify the causal relationship between cognitive activities and MCI, further studies are required.

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In particular, we provide a detailed description of clinical evidences upon the relationship between anti-angiogenic drugs and ONJ. Our data also indicate that the fibrotic fate is not only determined by the early inflammatory events but rather a complex process in which secondary events at later time points are important. Electronic searches of the controlled trial registers of The Cochrane Hepato-Biliary Group and The Cochrane Library, MEDLINE, BIOSIS, and EMBASE were combined (May 2000). By contrast, IL-10 enhanced ROI production and cell death in lupus PBL without affecting ROI levels and survival of control PBL. As TdP is frequently associated with QT-interval prolongation due to inhibition of the rapid activating delayed rectifier potassium channel in the heart (hERG channel), the properties of such blockers were investigated by molecular modeling and semi-empirical AM1 molecular orbital calculations. Quantification of carbohydrate structures in size fractionated aquatic humic substances by two-dimensional nuclear magnetic resonance. These insights, alongside the underlying, adaptable modelling framework presented here, will be valuable for supporting in silico pre-trial planning and post-hoc evaluation of HIV-1 vaccination or antibody treatment trials. The C-terminal fragment of DNlg2 instead of the full-length or non-cleavable DNlg2 is able to rescue neuromuscular junction defects and GluRIIB reduction induced by dnlg2 deletion. Associations with anaphylaxis and adrenaline prescription were explored among patients. A combination of rifaximin and neomycin is most effective in treating irritable bowel syndrome patients with methane on lactulose breath test.

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Outcomes of the group receiving olanzapine were compared with their own baseline status and with outcomes of the reference group. Instead, Wnt regulated Vsx1 expression, but not the expression of other retinal cell markers tested. This study was undertaken to analyse the incidence of cutaneous lymphomas in Tokyo. Detect features of microflora of upper respiratory tract on the example of flora of palatine tonsils and level of antibodies against intracellular parasites as markers of etiologic factors of respiratory infections in school-age children in remission period. To evaluate the association between carrier screening and CF birth incidence. Nitric oxide involvement in the anxiogenic-like effect of substance P. In this setting the stabilization/destabilization effects of the abruptness rate in density dependence, of the survival rates and of the competition coefficients are analysed.

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A patient with the sick sinus syndrome accompanying mirror-image dextrocardia which was associated with double superior venae cavae and an absent inferior vena cava is presented. We consider the equilibrium relaxation properties of the end-to-end distance and of the principal components in a one-dimensional polymer chain model with nonlinear interaction between the beads. The binding of Mig to bovine serum IgA was competitively inhibited by unlabelled Mig, intact and truncated alpha(2)-M receptors, and bovine serum IgA, but not by the Mig-IgG receptor, H-IgA or B-IgG. Understanding the cultural, ethnic, and socioeconomic factors in a postdisaster situation is crucial to helping special populations overcome debilitating mental illness and declining quality of life. Large and significant cancer risks for Japanese survivors exposed to less than 20 mSv external radiation from the atomic bombs in 1945 cast doubt on the ICRP recommended annual occupational dose limit. Elimination of transient pulmonary vein recurrences (dormant PVs) induced by an ATP injection and ablation at the PV carina region is an effective strategy for atrial fibrillation (AF) ablation.

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Memory tasks were administered to 14 high-functioning individuals with autism and 14 typically developing individuals matched on chronological age and verbal intelligence. We find that light-evoked excitatory postsynaptic currents (L-EPSCs) are mediated by AMPA and N-methyl-d-aspartate receptors in IP cells. Hydrodynamic theory of electromagnetic fields in continuous media. The spermatocytes containing the E segments, however, did not comprise whole cysts. Partitioning of the data according to subjects categorized as fast and slow habituators brought some organization consistent with the notion that the former are more advanced than the latter. Flexibility in the coordination chemistry of the 2,3-dimethylindolide ligand with potassium, yttrium, and samarium. The low correlation between estimated and actual body fatness in both genders indicates that Japanese university students, especially women, inaccurately estimate their percentage of body fat. However, phenotypic variation often changes due to environmental conditions, which may lead to poor classification, if environmentally induced variation in phenotypes is not accounted for. AID: To investigate the role of suprasegmental (anxious disorders) and segmental vegetative disorders (dysfunction of neuromuscular transmission and cutaneous microcirculation) in pathogenesis of muscular syndrome of rheumatoid arthritis (RA).

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The imodium instant 2 mg dosage chromophore is located in the interior of the protein with the nitrogen of the Schiff base between helices 2 and 6 and with its ring in the vicinity of helix 4. Rhinosinusitis treatment protocol: changing provider habits in primary care. CD measurements between pH 10 and 12 demonstrated that the buried tyrosines are strongly hydrogen bonded and are probably responsible to a considerable extent for the stability of this protein. The present results showed that lead could induce toxicity in PC12 cells after 24 hours with as little as 1 muM in a concentration-dependent manner. Peering over the chasm: Diffusion of prostate radiation therapy hypofractionation. After arthroscopic debridement, the treatment of knee OA with liver-softening medicine in conjunction with glucosamine is a feasible and effective solution.

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Baseline characteristics of LDL and HDL particles were evaluated for the prediction of AIS and short-term mortality after AIS. Thus, the developing visual pathways are repetitively stimulated by light for cumulatively over 3h before the breeding period ends. Based on its anabolic properties, treatment with the beta(2)-adrenoceptor agonist, clenbuterol, has been proposed as a strategy for ameliorating the symptoms of muscular dystrophy. Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cells. Totally 538 senior high school students of grade one were investigated by Test Anxiety Scale (TAS), Eysenck Personality Questionnaire (EPQ) and Self-Esteem Scale (SES) in a Senior High School in Shandong Province. Stereotactic body radiation therapy: a treatment in need of basic biological research. Tumor-bearing mice treated with IL-17E showed a significant increase in serum levels of IL-5 and increased numbers of eosinophils in peripheral blood compared to the control group. To evaluate complications, functional outcome, and mortality for both surgical methods, IF and hemiarthroplasty (HAP), in older patients suffering from femoral neck fracture with or without dementia.

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