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Altrol (Anastrozole)
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Altrol

Altrol is used to treat breast cancer in women who have gone through menopause. Some types of breast cancer depend on estrogen to grow, and this medicine can stop tumor growth by blocking estrogen production.

Other names for this medication:
Altraz, Altrol, Anabrez, Anastrocare, Anastrozole, Anatero, Anazol, Armilon, Armotraz, Femistra, Femitraz, Qubol, Redest, Rimidex, Stazonex, Xenosoul

Similar Products:
Adalat, Yasmin, Dilantin, Eldepryl, Imuran, Fosamax, Levothroid, Coreg, Epivir, Lipitor, Antialer, Andic, Ambrolite, Lorazine, Angizaar, Anazol,

Also known as: Anastrozole

Description

Altrol is approved to treat certain types of breast cancer in women who’ve gone through menopause.

What breast cancer is

Breast cancer develops when cells in your breast start to grow and multiply (make more cells) more quickly than usual. With most breast cancers, the abnormal cells are encouraged to grow by the hormone estrogen.

If your breast cancer is stimulated by hormones, such as estrogen, certain tests will show that the cancer cells have receptors (attachment sites) for those hormones. This type of breast cancer is called hormone receptor-positive (HR+).

HR+ cancers can be treated with hormone therapies that lower the estrogen level in your body. And because most breast cancer is HR+, hormone therapies are also sometimes used to treat breast cancer whose receptor status isn’t known.

What Altrol does

Altrol is a hormone therapy that’s used to treat certain forms of breast cancer. It’s a type of drug called an aromatase inhibitor. Altrol works by stopping (inhibiting) the action of an enzyme called aromatase. (Enzymes are certain proteins that help chemical reactions to happen inside your body.)

The aromatase enzyme makes estrogen out of steroid hormones in your body, such as testosterone. Aromatase is found in various tissues, including your brain, fat, and skin.

Before menopause, estrogen is mainly produced by your ovaries. And just a small amount is made by the aromatase enzyme. But after menopause, your ovaries stop producing estrogen. At that point, the aromatase enzyme is the main way that your body makes estrogen. (And in men, estrogen is also mainly produced by the aromatase enzyme.)

By stopping aromatase from working, Altrol lowers the amount of estrogen in your body. This helps to stop estrogen from encouraging breast cancer to grow and spread.

How long does it take to work?

Altrol will start working soon after you begin taking it. But you won’t be able to notice this. Your doctor may order different kinds of tests during your treatment to check and see if the drug is working for you.

Dosage

The following information describes Altrol dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Altrol comes as 1-mg tablets that are taken by mouth.

Dosage for breast cancer

The usual dosage of Altrol for breast cancer is one tablet taken once a day. It’s best to take your dose at the same time each day.

What if I miss a dose?

If you forget to take a dose of Altrol, take the missed dose as soon as you remember. However, if it’s almost time for your next dose, just skip the missed dose and take your next dose as usual. Don’t take two doses together to make up for a missed dose.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Altrol is meant to be used as a long-term treatment for breast cancer. If you and your doctor determine that Altrol is safe and effective for you, you’ll likely take it long term.

The length of time that you’ll take this drug depends on the type of cancer you’re using it to treat. Below we describe the typical length of time that Altrol is given. But to know for sure how long you should take Altrol, talk with your doctor.

For advanced breast cancer

If you’re taking Altrol to treat advanced breast cancer, you’ll usually take the drug for as long as your doctor feels this treatment is right for you. (With advanced breast cancer, the cancer has either spread to nearby areas or lymph nodes, called locally advanced breast cancer, or spread to other parts of your body, called metastatic breast cancer.)

For early breast cancer

If you’re taking Altrol as adjuvant treatment of early breast cancer, you’ll usually take the drug for at least 5 years. Adjuvant treatment is used to lower the risk of your breast cancer coming back or spreading after it’s already been treated with surgery. (With early breast cancer, the cancer hasn’t spread out of either your breast or the lymph nodes in your armpit.)

It’s not currently known if Altrol should be continued after these 5 years. And if so, it’s not known for how long after the first 5 years it should be taken.

Some studies found that breast cancer is less likely to come back if an aromatase inhibitor is taken for an additional 5 years after the first 5 years of adjuvant therapy. (Aromatase inhibitors are a class of medications.) With this approach to treatment, the drug would be taken for a total of 10 years. However, other studies didn’t show a benefit for extending the treatment beyond 5 the usual years.

In addition, one recent study found that taking Altrol for a total of 10 years didn’t provide any more benefit than taking it for a total of 7 years.

How long you take Altrol for early breast cancer will depend on how likely your breast cancer is to come back. It will also depend on your risk of side effects from treatment.

Overdose

If you overdose Generic Altrol and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Altrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Altrol if you are allergic to Generic Altrol components. This medicine has been shown to cause harm to the human fetus. It is unknown if this drug is excreted in breast milk. Use a non-hormonal method of birth control if you are a woman capable of becoming pregnant. Avoid alcohol. Avoid machine driving. Do not stop taking Generic Altrol suddenly.

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Cultures affect human social behaviors including moral decision making. We believe that for street-based interviews, respondents may disclose more sensitive information than telephone and household interviews. Valve failure was diagnosed by echocardiography and confirmed at operation. The second alternative interpretation suggests an analogy in vivo to mesenchymal-cell clonal attenuation observed in vitro. After endothelial removal with intraluminal saponin, the dilation was reduced and the constriction was enhanced significantly. The discovery of an abundant, novel transcript, lengsin, and a major novel splice form of MP19 reflect the utility of unamplified libraries constructed from dissected tissue. They also demonstrated unexpectedly high product selectivity for the Morita-Baylis-Hillman reaction of formaldehyde with methyl acrylate at high temperatures. Domiciliary health and welfare services for the elderly in Glasgow: use and need.

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Male Sprague-Dawley rats were randomized to four groups: sham group, I/R control group, NR1-1 group (rats treated with NR1, 20 mg.kg.d) and NR1-2 group (rats treated with NR1, 40 mg.kg.d). Folding of small disulfide-rich proteins: clarifying the puzzle. Prostate cancer cells use genetic and epigenetic mechanisms for progression to androgen independence. Factors influencing the variable expression of xanthelasmata and corneal arcus in familial hypercholesterolaemia. A microphotometric study of the kinetics of the histochemical reaction to lactate dehydrogenase. Given that the number of women admitted to hospitals with CHF each year exceeds the number of men, there is an obvious need to specifically and definitively evaluate the pharmacologic therapy of CHF in women. Evaluation of an cleocin t topical gel adjustment group for people with multiple sclerosis: a pilot randomized controlled trial. Slow forms of this transcript and of kinase-labeled linear viroid RNA persisted for longer than 20 minutes when incubated with a protein-rich extract prepared from the nuclei of uninfected tomato plants, although both were slowly cleaved by a nuclease present in this extract. However, the NADPHd activities markedly decreased in muscle layers, especially in the deep muscular layer on day 1 and 3, but quickly recovered by day 6.

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Influence of platform design of six different drug-eluting stents in provisional coronary bifurcation stenting by rePOT sequence: a comparative bench analysis. It performs various functions in the colon cancer cells such as inflammation, activates various cell types signaling and also promotes proliferation in colon cancer cells. However, its precise effects on the vascular tone of the transplanted organ have not been studied. Within-session decrement of the emission of licking bursts following reward devaluation in rats licking for sucrose. Meanwhile, the immunofluorescent staining showed marked stronger nuclear intensity of hALP protein in H2O2-treated HeLa cells. Previous data showed that aging of the central nervous system (CNS) is associated with widespread changes in tachykinin gene expression. Stability criteria are deduced and predictions of the theory compared with published observations. It was noted that the outer PDLA shell could facilitate POSS-(PDMAEMA-b-PDLA)8 to be well-dispersed in PLLA matrix through stereocomplex (SC) interaction, and the inner PDMAEMA shell endowed PLLA with good hydrophilicity. Moreover, we observed that the greatest coincidence of retrograde cell labeling was within the pallidal thalamic territory following the SMA injections and within the cerebellar thalamic territory following the MI injections. Competence formation produced by a transient exposure to PDGF was not effected by mGBG.

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We studied 55 patients admitted during 14 months to two inpatient psychiatric units of a municipal hospital who exhibited one or more of the catatonic signs of mutism, stereotypy, posturing, catalepsy, automatic obedience, negativism, echolalia/echopraxia, or stupor. Treatment with NZ reduced the capability of MSCs to promote the migration and the clonogenic growth of the prostate cancer cell lines PC3 and DU145. Two XY females with ovarian gonadal differentiation and typical clinical features of campomelic dysplasia could be tested for H-Y antigen and were found to be H-Y negative. Blood level of proinflammatory cytokine IL-1beta decreased in behaviorally passive rats, but increased in active animals after simultaneous immobilization and electrocutaneous stimulation. Molecular analysis by means of PCR and restriction fragment length polymorphism identified C neoformans genotype VNI.

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Prostaglandin production by rabbit isolated jejunum and its relationship to the inherent tone of the preparation. Breast elevation and compression decrease exercise-induced breast discomfort. The highest index--in Khanty-Mansy District--20.7, while a standard index--22.08. Forty-four children (66 ears) between 4 and 13 yr of age were evaluated for participation in the study. Although seizures are thought to originate in the medial temporal lobe in MTLE, it is important for involvement of the lateral temporal cortex to be also considered in some cases. Abdominal shotgun wound with pellet embolization leading to bilateral lower limb amputation: case report and review of the literature of missile emboli over the past 10 years. The influence of IGF-II on adrenal morphology and function was assessed in transgenic mice that postnatally overexpress IGF-II. Inadvertent sleep episodes are a recognized complication of sleep deprivation.

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