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Amitrip (Amitriptyline)

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Amitrip is used to treat depression. Compared to other antidepressants, it has a higher risk of side effects, such as weight gain and drowsiness. Amitrip is a tricyclic antidepressant (TCA). It works on parts of the brain responsible for raising levels of certain chemicals, like serotonin and norepinephrine, to help improve your mood.

Other names for this medication:
Amiline, Amitar, Amitin, Amitrip, Amitriptyline, Amitrix, Amity, Amixide, Amize, Amizep, Amoten, Amsha, Amypres, Anitryp, Arpidox, Bluneel, Cotrip, Crypton, Emotrip, Eptanol, Estiline, Gentrip, Limbitrol, Limbival, Lodep, Mitrip, Mitryp, Nextrip, Ristryl, Sarotena, Sereval, Tablin, Triplent, Tryline

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Also known as: Amitriptyline


Amitrip (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

Amitrip is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amitrip dosage information


If you overdose Amitrip and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Amitrip overdosage: seizures, loss of consciousness for a period of time, seeing things or hearing voices that do not exist, agitation, feeling drowsy, rigid muscles, vomiting, high temperature, cold body temperature, problems concentrating, abnormal heartbeats, confusion.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amitrip are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Amitrip if you are allergic to Amitrip components. Do not take Amitrip if you are pregnant, planning to become pregnant, or are breast-feeding. Be careful with Amitrip if you suffer from or have a history of a history of heart attack, stroke, bipolar disorder (manic-depression), schizophrenia or other mental illness, diabetes, overactive thyroid, glaucoma, problems with urination, heart disease, seizures. Be careful with Amitrip if you are taking guanethidine (Ismelin), disulfiram (Antabuse), heart rhythm medications such as flecainide (Tambocor), propafenone (Rhythmol), quinidine (Cardioquin, Quinidex, Quinaglute), cimetidine (Tagamet). Avoid alcohol. Be careful! Taking Amitrip you can become suicidal. Be careful when you are driving or operating machinery. Be careful with Amitrip if you are going to have a surgery. It can be dangerous to stop Amitrip taking suddenly.

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