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Supracetron

Supracetron is a medication used to prevent nausea and vomiting caused by cancer medications (chemotherapy), radiation therapy, and surgery. Supracetron works by blocking the actions of serotonin, a natural substance in your body, that may cause nausea and vomiting.

Other names for this medication:
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Also known as: Ondansetron

Description

Supracetron (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Supracetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.

Supracetron may be used for purposes not listed in this medication guide.

Dosage

This section provides information on the proper use of a number of products that contain ondansetron. It may not be specific to Supracetron. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral disintegrating tablet:

Make sure your hands are dry. Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet. Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

To use the oral soluble film:

Make sure your hands are clean and dry before and after using this medicine. Fold the pouch along the dotted line to expose the tear notch. While still folded, tear the pouch carefully along the edge and remove the film out from the pouch. Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole. Once the film is dissolved, you may swallow with or without water.

If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (oral disintegrating tablets, solution, or tablets): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days. Children 4 to 11 years of age—At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment. Children younger than 12 years of age—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) one hour before anesthesia is given. Children—Use and dose must be determined by your doctor. For oral dosage form (soluble film): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days. Children 4 to 11 years of age—At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—One 8-milligram (mg) film three times a day. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Supracetron and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the unused soluble film in the foil pouch until you ready to use it.

Detailed Supracetron ODT dosage information

Side effects

The most common side effects associated with Supracetron are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Supracetron ODT if:

you are also using apomorphine (Apokyn); or you are allergic to Supracetron ODT or similar medicines (dolasetron, granisetron, palonosetron).

To make sure Supracetron ODT is safe for you, tell your doctor if you have:

liver disease; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); congestive heart failure, slow heartbeats; a personal or family history of long QT syndrome; or a blockage in your digestive tract (stomach or intestines).

Supracetron ODT is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Supracetron ODT is not approved for use by anyone younger than 4 years old.

Supracetron ODTly disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

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Opioid administration increased low MV events correlating with increased LOS. Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists. An international referral center for the diagnosis and management of mitochondrial disorders. Severe ischemic colitis after treatment of bile-duct cancer using gemcitabine and cisplatin. Based on evidence from pivotal multinational clinical trials as well as recent studies in Asia, including Korea, lenalidomide/dexamethasone is an effective treatment option for patients with RRMM, regardless of age or disease status. Together with the properties of intrinsic retinal stem cell-related gene expression, we found SLCCs can be induced into neuron-like cells that express glial fibrillary acidic protein and rhodopsin (a photoreceptor cell marker). This study assesses the effects of treatment over an extended follow-up period of up to a year.

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Control of FNR function of Escherichia coli by O2 and reducing conditions. Obstetricians and midwives completed a widely-used questionnaire on UCC practices. Clinical evaluations were performed 1 week before and 3 months after surgery. Sibling Relation, Ethnic Prejudice, Direct and Indirect Contact: There is a Connection?. Phenobarbital-responsive sialadenosis (PRS) is a rare idiopathic disease in dogs. Relationships Between RNA Polymerase II Activity and Spt Elongation Factors to Spt- Phenotype and Growth in Saccharomyces cerevisiae. Not all the pigs showed clinical signs, but Nipah virus was recovered from the nose and oropharynx of both clinically and sub-clinically infected animals. Both serine and aspartate protease inhibitors failed to inhibit enzyme activity.

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Our findings also emphasize the key role of patient experience measures in the evaluation of medical homes. The oscillatory shear index (OSI) was developed based on the hypothesis that intimal hyperplasia was correlated with oscillatory shear stresses. We further demonstrated that nonphosphorylated cleaved Sox2 specifically induces the expression of proneural genes and promotes neurogenic commitment in vivo Our present study sheds light on how the level of Cdk kinase activity directly regulates Sox2 to tip the balance between self-renewal and differentiation in NSCs. Labeling is also seen in the interneuronal basket cells projecting onto the Purkinje cells. We investigated the expression and function of sFRP1 in uterine leiomyomas. HO-1 transfection resulted in increased expression of HO-1 protein and reduced cell injury during cold storage. The amplitude differences between groups may implicate frontal attentional processes in Down syndrome as opposed to more posterior processes. Surprisingly, none show a straightforward relationship between local extinction and limited tolerances to high temperature.

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The aim of this study was to assess the feasibility, safety and efficacy of percutaneous radiofrequency ablation of lung metastases from colorectal carcinoma using C-arm cone beam computed tomography (CBCT) guidance. The transcriptional regulatory network inferred by PECA provides a detailed view of how trans- and cis-regulatory elements work together to affect gene expression in a context-specific manner. A possible interpretation of these observations is the following: the binding proteins occupy sites near the bacterial surface, and they may be components of active transport systems responsible for the concentrative uptake of these nutrients. The contribution of surgeons to the evolution of endoscopic applications and its practice is a triggering factor for the improvement of endoscopic instruments and their widespread use. Detection of a subtle rearrangement of chromosome 22 using molecular techniques. To compare live-birth rates, blastocyst to live-birth efficiency, gestational age, and birth weights in a large cohort of patients undergoing single versus double thawed blastocyst transfer. The following scales were utilized: scale for assessment of positive symptoms (SAPS), scale for assessment of negative symptoms (SANS), Brief Cope scale, Self report Quality of life for schizophrenia (SQLS), three subtest short form of WAIS. We report a case of schwannoma arising from infra-orbital nerve in a 40-year-old male patient. In this study, the in vitro and in vivo antibiotic release from this type of bone defect filler was characterized. Lastly, an inverted pendulum model is given to show the advantages and effectiveness of the proposed results.

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Pretreatment with NG-nitro-L-arginine methyl ester (L-NAME) eyedrops caused a significant inhibition of the clinical score and the vascular permeability after challenge with either antigen, histamine or PAF. In Arabidopsis, euchromatic TEs are targeted by RNA-directed DNA methylation (RdDM). Nitro-derivatives of 1-phenyl-5-sulfanilamidopyrazole and of 1-phenyl-3-methyl-5-sulfanilamidopyraole. Participants were veterans referred for neuropsychological evaluation from a rural CBOC 115 miles from the regional VAMC. These results indicate that, under moderate compression, sites of increased stress vary depending on the morphology of each spinal cord segment or the shape of compression components, and also that the variability of symptoms may depend on the direction of compression. With regard to the initial DNA extraction from clinically relevant samples, a number of commercially available kits are commonly used and are also designed to be easy to handle and less labor-intensive. Furthermore, the developmental status of seeds and specific tissue types exert conditional influences during fungal colonization. The diagnosis of canine heartworm infection is based upon the presence of circulating Dirofilaria immitis microfilariae or on techniques for the detection of serum antibodies or antigens. Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage.

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SH2-B(-/-) cumulus cells do not respond to either follicle-stimulating hormone or IGF-I. Health care transitions: perceptions from older patients in Rhode Island. Trileaflet Mitral Valve with Three Papillary Muscles Associated with Hypertrophic Cardiomyopathy: A Novel Case. EP studies included mixed nerve EPs (ulnar and median or tibial nerve), and either C6 and C8 or L4, L5, and S1 dermatomal EPs for cervical and lumbar disorders, respectively. Digital technology in the early 21st century has introduced significant changes to everyday life and the ways in which we practise medicine. Lexical decision as an endophenotype for reading comprehension: an exploration of an association. Therefore, anatomic PCL reconstruction cannot be completed simply performed merely with straight bundles and circular bone tunnels. Chronic hepatitis C - what do the new drugs offer and who should get them first?. Indeed, the increase in serum phosphate levels is only a reflection of underlying complex mechanisms, and many important factors play a role including parathyroid hormone, vitamin D, fibroblast growth factor 23 (FGF23), and others. Biological agents such as IL-2, IL-12, IL-11 and/or IL-18 alone or in combination with HGFs should be considered for future studies to identify new approaches to enhance neonatal host defense, and thereby decrease the incidence of neonatal sepsis and the consequent high risk of morbidity and mortality.

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This series of qualitative interviews was launched by The Lancet Commission on Global Surgery (LCoGS) with the aim of understanding the contextual challenges-the specific circumstances-faced by surgical care providers in low-resource settings who care for impoverished patients, and how those providers overcome these challenges. A nickel-catalyzed deamidative cross-coupling reaction of amides with terminal alkynes as coupling partners was disclosed. Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection. A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinase activation and induction of proliferation in T cells. Our aim was to reveale the features of histological mucosa with different composition of the microflora of stomach and duodenum in children with chronic gastroduodenitis. Risk factors associated to upper gastrointestinal bleeding in non intensive care units. The isoenzymes of glutamic-oxalacetic transaminase in myocardial infarct. When considering all of the photosensitive proteins, particularly those in microbial lineages, an image of evolutionary flexibility is emerging, with examples of fusion proteins from multiple types of photosensors and photosensitive domains shared among diverse arrays of proteins. Early change scores, equal to minimal detectable change scores on patient-reported outcomes appear to be strong indicators that patients with shoulder pain are on a positive trajectory to benefit from rehabilitation.

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ERPs were recorded in 17 unmedicated civilian PTSD patients and 17 age- and sex-matched controls during a conventional auditory oddball task. Pharmacological treatment may sometimes be necessary and mainly relies on volume expansion by fludrocortisone and/or a vasopressor agents such as midodrine. A 19-year-old man was referred for evaluation of possible hereditary hyperferritinemia-cataract syndrome. When isogenic wild-type, revS and complemented revS strains were tested in a mouse myonecrosis model, the revS mutant was found to be attenuated in virulence, which was similar to the attenuation observed previously with the revR mutant. The diversity of proteins that localize to INQ indicates that other biological processes such as cell cycle progression, chromatin and mitotic spindle organization may also be regulated through INQ. The patient showed severe hypodontia, microdontia and short roots. We estimated microbiological pNTM disease prevalence by multiplying all pTB cases in each area with the ratio of pNTM cases and pTB cases at the survey hospitals in each area. To investigate the sensitivity of human Schwann cells to cisplatin (cis-DDP), different approaches to estimate DNA damage were used: the comet assay, morphological evaluation of the granular condensation of nuclear chromatin and the terminal transferase-mediated dUTP nick-end-labelling (TUNEL) method. Resistance to antibiotics of 150 Shigella strains isolated in France.

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The repressive Hippo pathway has a profound tumour suppressive role in cancer by restraining the growth-promoting function of the transcriptional coactivator, YAP. Conjugation also mediates gene transfer from bacteria to eukaryotic organisms, including yeast and human cells. Body weight and nasal and pharynx patency seem to neurontin dose renal be the main determinants of snoring. Fibrinolytic measurements included euglobulin clot lysis time (ELT), fibrinogen, plasminogen activator inhibitor 1, and tissue-type plasminogen activator. Finally, results from analysis in patients were correlated with clinical data and extensive sets of routine and experimental biomarkers. Oral pharmacokinetics and in-vitro metabolism of metyrapone in male rats. After restoration of vital signs, surgery was performed without complications. Revascularization Strategies in Women with Stable Cardiovascular Disease: What do the Trials Reveal?.

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Skeletal muscle microvascular blood flow and oxygen transport in patients with severe sepsis. Northern blot showed that MDZF mRNA was restrictedly expressed in heart, skeleton muscle, kidney, liver, and placenta. PSV has been increasingly used as a partial ventilatory support for various types of respiratory failure. Transoesophageal echocardiography in patients without arterial and major cardiac sources of embolism: difference between stroke subtypes. The majority of the antibodies induced in response to seasonal vaccination are strain-specific. Further investigation is needed to determine whether these results will change over time. In addition, axons within the white matter of the brainstem and caudal CNS areas were labelled, with the most intense labelling seen within the white matter of the spinal cord. Electrode impedances were measured by using the standard telemetry function of the system. A 24-year-old female presented to her general practitioner with shortness of breath.

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Growth factor (GF)-based therapies can be more effective when concerns such as GF spatiotemporal presentation, bioactivity, bioavailability, and localization are addressed. In morbidly obese women without other comorbidity, nonmedically indicated induction was not associated with an increased risk of cesarean delivery. Here we show that deletion of exon-5B (specific for SM-B) in the gene for the heavy chain of smooth muscle myosin results in a complete loss of SM-B myosin and switching of splicing to the SM-A isoform, without affecting SM1 and SM2 myosin content. Antigenic comparison of two substrains of Entamoeba histolytica by gel diffusion and immunoelectrophoresis. It revealed that, although the naprosyn 750 mg microvilli were present on all sides of the cell in the dispersed stage and in the attached stage, they were not present on the bottom of the cell when it was stretched on the surface of the dish.

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RVM is based on Bayesian estimation theory, of which a distinctive feature is that it can yield a sparse decision function that is defined by only a very small number of so-called relevance vectors. Centre- and provider-level factors play an important role in shaping practice differences in the management of childhood nephrotic syndrome. Measurement of surrogate mast cell-related products in blood or urine is often performed to assess disease extent in evaluating patients with mastocytosis. Positively charged cyanines interact with QDs surface which is negatively charged due to capping agent carboxylate ions. Our data suggest that different levels and timing of Bmi1 overexpression yield distinct cellular outcomes within the same cellular lineage. Expression and regulation of mouse selenoprotein P transcript variants differing in non-coding RNA. Recently published consensus guidelines and a pyridium dosing pediatric checklist provided herein may help facilitate improvement of diagnostic concordance and thereby reduce over-interpretation and potential overtreatment. Mice were injected with naked DNA intramuscularly, and both the cellular and humoral immune responses were compared to those elicited in mice immunized with recombinant protein. This algorithm achieves the goal of segmentation via design of an iterative approach that extracts the structure through voting of feature vectors formed by distance, local intensity gradient, and median measures.

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The patients were categorized into original and generic levodopa groups. Comparison of relationship between salivary electrolyte levels and dental caries in children with Down syndrome. Synthesis and characterization of star-shaped oligo(ethylene glycol) with tyrosine derived moieties under variation of their molecular weight. The HIV status of the patients was recorded in the routine TB laboratory form and TB laboratory register. Relative age appears to be a very important factor for the development of expertise among male Japanese baseball players and involves long-term disadvantages after becoming professional players. Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2. By day 1, and extending through 4 days following kainic acid-induced seizures, brains from DNA-PKcs null mice showed widespread neurodegeneration that encompassed the entire hippocampal CA1-CA3 pyramidal cell layer, entorhinal cortex, and lateral septum, with relative sparing of the dentate gyrus granule cell layer and hilus, as judged by toluidine blue, Fluoro-Jade B, and terminal dUTP nick end labeling staining. Dysexecutive syndrome in amnesic mild cognitive impairment: a multicenter study.

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